Serological evidence of Mayaro virus infection in blood donors from São Carlos, São Paulo, Brazil.

Autor: Romeiro MF; Virology Research Center, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, São Paulo state, Brazil., Fumagalli MJ; Virology Research Center, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, São Paulo state, Brazil., Dos Anjos AB; Virology Research Center, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, São Paulo state, Brazil.; Banco de Sangue da Irmandade da Santa Casa de Misericórdia de São Carlos, São Carlos, São Paulo state, Brazil., Figueiredo LTM; Virology Research Center, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, São Paulo state, Brazil.
Jazyk: angličtina
Zdroj: Transactions of the Royal Society of Tropical Medicine and Hygiene [Trans R Soc Trop Med Hyg] 2020 Sep 01; Vol. 114 (9), pp. 686-689.
DOI: 10.1093/trstmh/traa016
Abstrakt: Background: Human infections by Mayaro virus (MAYV) occur by insect bites upon exposure to rural or sylvatic areas. Information regarding MAYV transmission is limited due to a lack of commercial diagnostic assays and diagnostic confusion on account of similarities of clinical signs with other co-circulating arboviral diseases.
Methods: A serological survey of MAYV and Chikunguya virus (CHIKV) antibodies was performed by ELISA. Between 2017 and 2018, 5608 blood donor samples were tested.
Results: Specific IgM and IgG antibodies to MAYV were detected respectively in 36 and 11 samples, indicating a total seroprevalence of approximately 0.83%. Neutralization activity was observed in two IgG positive sera. Additionally, eight distinct samples had IgM antibodies to CHIKV alone.
Conclusions: Our data suggest previously unreported circulation of MAYV in São Carlos city, from southeastern Brazil.
(© The Author(s) 2020. Published by Oxford University Press on behalf of Royal Society of Tropical Medicine and Hygiene.)
Databáze: MEDLINE
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