Comparative pathogenesis of COVID-19, MERS, and SARS in a nonhuman primate model.

Autor: Rockx B; Department of Viroscience, Erasmus University Medical Center, Rotterdam, Netherlands. b.rockx@erasmusmc.nl b.haagmans@erasmusmc.nl., Kuiken T; Department of Viroscience, Erasmus University Medical Center, Rotterdam, Netherlands., Herfst S; Department of Viroscience, Erasmus University Medical Center, Rotterdam, Netherlands., Bestebroer T; Department of Viroscience, Erasmus University Medical Center, Rotterdam, Netherlands., Lamers MM; Department of Viroscience, Erasmus University Medical Center, Rotterdam, Netherlands., Oude Munnink BB; Department of Viroscience, Erasmus University Medical Center, Rotterdam, Netherlands., de Meulder D; Department of Viroscience, Erasmus University Medical Center, Rotterdam, Netherlands., van Amerongen G; Viroclinics Xplore, Schaijk, Netherlands., van den Brand J; Department of Viroscience, Erasmus University Medical Center, Rotterdam, Netherlands., Okba NMA; Department of Viroscience, Erasmus University Medical Center, Rotterdam, Netherlands., Schipper D; Department of Viroscience, Erasmus University Medical Center, Rotterdam, Netherlands., van Run P; Department of Viroscience, Erasmus University Medical Center, Rotterdam, Netherlands., Leijten L; Department of Viroscience, Erasmus University Medical Center, Rotterdam, Netherlands., Sikkema R; Department of Viroscience, Erasmus University Medical Center, Rotterdam, Netherlands., Verschoor E; Department of Virology, Biomedical Primate Research Centre, Rijswijk, Netherlands., Verstrepen B; Department of Virology, Biomedical Primate Research Centre, Rijswijk, Netherlands., Bogers W; Department of Virology, Biomedical Primate Research Centre, Rijswijk, Netherlands., Langermans J; Animal Science Department, Biomedical Primate Research Centre, Rijswijk, Netherlands.; Population Health Sciences, Unit Animals in Science and Society, Faculty of Veterinary Medicine, Utrecht University, Netherlands., Drosten C; Institute of Virology, Charité-Universitätsmedizin, Berlin, Germany., Fentener van Vlissingen M; Erasmus Laboratory Animal Science Center, Erasmus University Medical Center, Rotterdam, Netherlands., Fouchier R; Department of Viroscience, Erasmus University Medical Center, Rotterdam, Netherlands., de Swart R; Department of Viroscience, Erasmus University Medical Center, Rotterdam, Netherlands., Koopmans M; Department of Viroscience, Erasmus University Medical Center, Rotterdam, Netherlands., Haagmans BL; Department of Viroscience, Erasmus University Medical Center, Rotterdam, Netherlands. b.rockx@erasmusmc.nl b.haagmans@erasmusmc.nl.
Jazyk: angličtina
Zdroj: Science (New York, N.Y.) [Science] 2020 May 29; Vol. 368 (6494), pp. 1012-1015. Date of Electronic Publication: 2020 Apr 17.
DOI: 10.1126/science.abb7314
Abstrakt: The current pandemic coronavirus, severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2), was recently identified in patients with an acute respiratory syndrome, coronavirus disease 2019 (COVID-19). To compare its pathogenesis with that of previously emerging coronaviruses, we inoculated cynomolgus macaques with SARS-CoV-2 or Middle East respiratory syndrome (MERS)-CoV and compared the pathology and virology with historical reports of SARS-CoV infections. In SARS-CoV-2-infected macaques, virus was excreted from nose and throat in the absence of clinical signs and detected in type I and II pneumocytes in foci of diffuse alveolar damage and in ciliated epithelial cells of nasal, bronchial, and bronchiolar mucosae. In SARS-CoV infection, lung lesions were typically more severe, whereas they were milder in MERS-CoV infection, where virus was detected mainly in type II pneumocytes. These data show that SARS-CoV-2 causes COVID-19-like disease in macaques and provides a new model to test preventive and therapeutic strategies.
(Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.)
Databáze: MEDLINE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje