Protein C and Anti-Thrombin-III Deficiency in Children With Beta-Thalassemia.

Autor:	Abd El Mabood S; Hematology, Oncology and Bone Marrow Transplantation Unit, Pediatric Department, Faculty of Medicine, Mansoura University, Egypt., Fahmy DM; Pediatric Department, Faculty of Medicine, Mansoura University, Egypt., Akef A; Clinical Pathology Department, Faculty of Medicine, Mansoura University, Egypt., El Sallab S; Neonatal Intensive Care Unit, Pediatric Department, Faculty of Medicine, Mansoura University, Egypt.
Jazyk:	angličtina
Zdroj:	Journal of hematology [J Hematol] 2018 May; Vol. 7 (2), pp. 62-68. Date of Electronic Publication: 2018 May 10.
DOI:	10.14740/jh392w
Abstrakt:	Background: Thromboembolic events (TEEs) are recently described complications in thalassemia patients. Many mechanisms were postulated for thrombosis. Conflicting results of natural anticoagulants values were reported in previous studies. Our aim was to investigate protein C and anti-thrombin-III (AT-III) levels in thalassemics and to detect risk factors for their decrement. Methods: A cross-sectional study for 60 beta-thalassemia patients (35 major and 25 intermedia) and 35 healthy children were tested for protein C and AT-III levels, liver function tests and Sr. ferritin. Results: A significant reduction in protein C and AT-III levels was noticed in patient group compared to healthy children (82.50% (32 - 175) vs. 104% (60 - 204), P = 0.041 and 237.52 ± 53.19 mg/L vs. 322.99 ± 56.57 mg/L, P value ≤ 0.001, respectively). Protein C was lower among older patients (> 10 years) than younger patients (< 10 years), and splenectomized category than non-splenectomized one (P = 0.02 and 0.011, respectively). AT-III was significantly lower among splenectomized patients as compared to those who did not undergo splenectomy (P = 0.04). Significant correlations were found between protein C and AT-III with older age and liver functions. Conclusions: Protein C and AT-III were significantly lower among thalassemics with the main risk factors for their deficiencies being: splenectomy and increasing age. This allows establishment of early prophylactic policy against TEE for the vulnerable group. Competing Interests: None of the authors has any conflict of interest. (Copyright 2018, Abd El Mabood et al.)
Databáze:	MEDLINE
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