Marking axillary nodes with 4% carbon microparticle suspension before neoadjuvant chemotherapy improves sentinel node identification rate and axillary staging.

Autor: Spautz CC; Department of Gynecology and Obstetrics, Clinical Hospital of Federal University of Paraná, Curitiba, Paraná, Brazil.; Division of Breast Unit, Hospital Nossa Senhora das Graças, Curitiba, Paraná, Brazil., Schunemann Junior E; Department of Gynecology and Obstetrics, Clinical Hospital of Federal University of Paraná, Curitiba, Paraná, Brazil., Budel LR; Department of Gynecology and Obstetrics, Clinical Hospital of Federal University of Paraná, Curitiba, Paraná, Brazil., Cavalcanti TCS; Department of Pathology, Clinical Hospital of Federal University of Paraná, Curitiba, Paraná, Brazil., Louveira MH; Department of Radiology, Clinical Hospital of Federal University of Paraná, Curitiba, Paraná, Brazil., Junior PG; Department of Gynecology and Obstetrics, Clinical Hospital of Federal University of Paraná, Curitiba, Paraná, Brazil., Nissen LP; Division of Breast Unit, Hospital Nossa Senhora das Graças, Curitiba, Paraná, Brazil., Sobreiro BP; Division of Post-Graduation Programm, Positivo University Medical School, Curitiba, Paraná, Brazil., Dória MT; Department of Gynecology and Obstetrics, Clinical Hospital of Federal University of Paraná, Curitiba, Paraná, Brazil.; Division of Breast Unit, Hospital Nossa Senhora das Graças, Curitiba, Paraná, Brazil., Urban CA; Division of Breast Unit, Hospital Nossa Senhora das Graças, Curitiba, Paraná, Brazil.; Division of Post-Graduation Programm, Positivo University Medical School, Curitiba, Paraná, Brazil., Budel VM; Department of Gynecology and Obstetrics, Clinical Hospital of Federal University of Paraná, Curitiba, Paraná, Brazil.
Jazyk: angličtina
Zdroj: Journal of surgical oncology [J Surg Oncol] 2020 Aug; Vol. 122 (2), pp. 164-169. Date of Electronic Publication: 2020 Apr 14.
DOI: 10.1002/jso.25928
Abstrakt: Background and Objectives: Marking positive lymph nodes (LNs) before neoadjuvant chemotherapy (NAC) may improve the accuracy of sentinel lymph node biopsy (SLNB). The aim of this study was to determine the feasibility of marking LNs with 4% carbon microparticle suspension (CMS) before NAC and to evaluate if this technique would improve the SLNB identification rate.
Methods: A prospective study of patients with cT1-T4, cN1-N2 breast cancer who underwent US-guided fine-needle aspiration biopsy (FNAB) of suspected LNs and concomitant marking with 4% CMS was performed. After NAC, LNs marked with 4% CMS and those marked with Patent Blue V dye (PBV) were identified and resected.
Results: Of the 123 patients included, 74 (60.1%) had positive LNs at FNAB. During axillary surgery, 4% CMS was identified in 121 of 123 patients (98.3%) and blue sentinel LNs in 91% (112 of 123 patients) (P = .0103). Comparing isolated results of PBV and 4%CMS + PBV, the association was better in identifying positive LNs (72.2% vs 97.7%) (P = .02).
Conclusion: The association of 4% CMS and PBV is feasible and significantly increased the identification rate of positive LNs. 4% CMS may play an important role as a complementary technique in patients submitted to NAC.
(© 2020 Wiley Periodicals, Inc.)
Databáze: MEDLINE
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