Germline APOBEC3B deletion influences clinicopathological parameters in luminal-A breast cancer: evidences from a southern Brazilian cohort.

Autor: Vitiello GAF; Department of Pathological Sciences, Biological Sciences Center, Londrina State University, Londrina, Paraná, Brazil., de Sousa Pereira N; Department of Pathological Sciences, Biological Sciences Center, Londrina State University, Londrina, Paraná, Brazil., Amarante MK; Department of Pathological Sciences, Biological Sciences Center, Londrina State University, Londrina, Paraná, Brazil., Banin-Hirata BK; Department of Pathological Sciences, Biological Sciences Center, Londrina State University, Londrina, Paraná, Brazil., Campos CZ; Department of Clinical Research, Londrina Cancer Hospital, Londrina, Paraná, Brazil.; Department of Clinical Medicine, Health Sciences Center, Londrina State University, Londrina, Paraná, Brazil., de Oliveira KB; Department of Pathological Sciences, Biological Sciences Center, Londrina State University, Londrina, Paraná, Brazil., Losi-Guembarovski R; Department of General Biology, Biological Sciences Center, Londrina State University, Londrina, Paraná, Brazil., Watanabe MAE; Department of Pathological Sciences, Biological Sciences Center, Londrina State University, Londrina, Paraná, Brazil. maewat@uel.br.
Jazyk: angličtina
Zdroj: Journal of cancer research and clinical oncology [J Cancer Res Clin Oncol] 2020 Jun; Vol. 146 (6), pp. 1523-1532. Date of Electronic Publication: 2020 Apr 13.
DOI: 10.1007/s00432-020-03208-8
Abstrakt: Purpose: APOBEC3A and APOBEC3B cytidine deaminases have been implicated in the pathogenesis of multiple cancers, including breast cancer (BC). A germline deletion linking APOBEC3A and APOBEC3B loci (A3A/B) has been associated with higher APOBEC-mediated mutational burden, but its association with BC risk have been controversial. Therefore, this study investigated the association between A3A/B and BC susceptibility and clinical presentation in a Brazilian cohort.
Methods: A3A/B deletion was evaluated through allele-specific PCR in 341 BC patients and 397 women without familial or personal history of neoplasia from Brazil and associations with susceptibility to BC subtypes were tested through age-adjusted logistic models while correlations with clinicopathological parameters were tested using Kendall's tests.
Results: No association was found between A3A/B and BC susceptibility; however, in Luminal-A BCs, it was positively correlated with tumor size (Tau-c = 0.125) and Ki67 (Tau-c = 0.116) and negatively correlated with lymph node metastasis (LNM) (Tau-c = - 0.162). The negative association between A3A/B with LNM in Luminal-A BCs remained significant even after adjusting for tumor size and Ki67 in logistic models (OR = 0.22; p = 0.008).
Conclusion: These results show that although A3A/B may not modify BC susceptibility in Brazilian population, it may affect clinicopathological features in BC subtypes, promoting tumor cell proliferation while being negatively associated with LNM in Luminal-A BCs.
Databáze: MEDLINE
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