Chronic sucralose consumption induces elevation of serum insulin in young healthy adults: a randomized, double blind, controlled trial.

Autor: Bueno-Hernández N; Laboratory of Proteomics and Metabolomics, Research Division, General Hospital of Mexico 'Dr. Eduardo Liceaga', Mexico City, Mexico., Esquivel-Velázquez M; Laboratory of Proteomics and Metabolomics, Research Division, General Hospital of Mexico 'Dr. Eduardo Liceaga', Mexico City, Mexico., Alcántara-Suárez R; Laboratory of Proteomics and Metabolomics, Research Division, General Hospital of Mexico 'Dr. Eduardo Liceaga', Mexico City, Mexico.; Clinical Nutrition Division, General Hospital of Mexico Dr. Eduardo Liceaga, Mexico City, Mexico., Gómez-Arauz AY; Laboratory of Proteomics and Metabolomics, Research Division, General Hospital of Mexico 'Dr. Eduardo Liceaga', Mexico City, Mexico., Espinosa-Flores AJ; Laboratory of Proteomics and Metabolomics, Research Division, General Hospital of Mexico 'Dr. Eduardo Liceaga', Mexico City, Mexico., de León-Barrera KL; Laboratory of Proteomics and Metabolomics, Research Division, General Hospital of Mexico 'Dr. Eduardo Liceaga', Mexico City, Mexico., Mendoza-Martínez VM; Laboratory of Proteomics and Metabolomics, Research Division, General Hospital of Mexico 'Dr. Eduardo Liceaga', Mexico City, Mexico., Sánchez Medina GA; Laboratory of Proteomics and Metabolomics, Research Division, General Hospital of Mexico 'Dr. Eduardo Liceaga', Mexico City, Mexico.; Division of Clinical Pharmacology Research Division, General Hospital of Mexico 'Dr. Eduardo Liceaga', Mexico City, Mexico., León-Hernández M; Division of Clinical Pharmacology Research Division, General Hospital of Mexico 'Dr. Eduardo Liceaga', Mexico City, Mexico., Ruiz-Barranco A; Clinical Nutrition Division, General Hospital of Mexico Dr. Eduardo Liceaga, Mexico City, Mexico., Escobedo G; Laboratory of Proteomics and Metabolomics, Research Division, General Hospital of Mexico 'Dr. Eduardo Liceaga', Mexico City, Mexico. gescobedog@msn.com., Meléndez G; Laboratory of Proteomics and Metabolomics, Research Division, General Hospital of Mexico 'Dr. Eduardo Liceaga', Mexico City, Mexico. guillermomelendezmier@outlook.es.; Clinic of Medical and Nutritional Trials (MENTRIALS), Mexico City, Mexico. guillermomelendezmier@outlook.es.
Jazyk: angličtina
Zdroj: Nutrition journal [Nutr J] 2020 Apr 13; Vol. 19 (1), pp. 32. Date of Electronic Publication: 2020 Apr 13.
DOI: 10.1186/s12937-020-00549-5
Abstrakt: Background: Non-nutritive sweeteners (NNS) are widely consumed by humans due to their apparent innocuity, especially sucralose. However, several studies link sucralose consumption to weight gain and metabolic derangements, although data are still contradictory.
Objective: To determine the effect of acute and chronic consumption of sucralose on insulin and glucose profiles in young healthy adults.
Material and Methods: This was a randomized, parallel, double-blind, placebo-controlled trial conducted in healthy young adults from 18 to 35 years old, without insulin resistance. A hundred thirty seven participants were randomized into three groups: a) volunteers receiving 48 mg sucralose, b) volunteers receiving 96 mg sucralose, and c) controls receiving water as placebo. All participants underwent a 3-h oral glucose tolerance test (OGTT) preceded by consuming sucralose or placebo 15 min before glucose load, at two time points: week zero (Wk0) and week ten (Wk10). Serum insulin and glucose were measured every 15 min during both OGTTs.
Results: Compared to Wk0, consumption of sucralose for 10 weeks provoked 1) increased insulin concentrations at 0 min (7.5 ± 3.4 vs 8.8 ± 4.1 μIU/mL; p = 0.01), 30 min (91.3 ± 56.2 vs 110.1 ± 49.4 μIU/mL; p = 0.05), 105 min (47.7 ± 24.4 vs 64.3 ± 48.2 μIU/mL; p = 0.04) and 120 min (44.8 ± 22.1 vs 63.1 ± 47.8 μIU/mL; p = 0.01) in the 48 mg sucralose group; 2) increased blood glucose at - 15 min (87.9 ± 4.6 vs 91.4 ± 5.4 mg/dL; p = 0.003), 0 min (88.7 ± 4 vs 91.3 ± 6 mg/dL; p = 0.04) and 120 min (95.2 ± 23.7 vs 106.9 ± 19.5 mg/dL; p = 0.009) in the 48 mg sucralose group; 3) increased area under the curve (AUC) of insulin in both 48 and 96 mg sucralose groups (9262 vs 11,398; p = 0.02 and 6962 vs 8394; p = 0.12, respectively); and 4) reduced Matsuda index in the 48 mg sucralose group (6.04 ± 3.19 vs 4.86 ± 2.13; p = 0.01).
Conclusions: These data show that chronic consumption of sucralose can affect insulin and glucose responses in non-insulin resistant healthy young adults with normal body mass index (between 18.5 and 24.9 kg/m 2 ), however, the effects are not consistent with dose; further research is required.
Clinical Trial Registry: NCT03703141.
Databáze: MEDLINE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje