| Autor: |
Lewis JP, Linman JW, Marshall GJ, Pajak TF, Bateman JR |
| Jazyk: |
angličtina |
| Zdroj: |
Cancer [Cancer] 1977 Apr; Vol. 39 (4), pp. 1387-96. |
| DOI: |
10.1002/1097-0142(197704)39:4<1387::aid-cncr2820390406>3.0.co;2-y |
| Abstrakt: |
One hundred and forty-seven adults with acute nonlymphocytic leukemia were randomized to one of two treatment regimens utilizing cytosine arabinoside and 6-thioguanine. In regimen A the drugs were administered every 12 hours until marrow cellularity was reduced by at least 50%. In regimen B the drugs were administered every 12 hours for 5 days with five to 7 days rest intervals between courses. Decisions to continue or reinstitute therapy were based solely on marrow cellularity and marrow ratings. The overall response in referee-verified cases in both groups was similar (41%); regimen B proved to be the easier protocol to administer but required greater support. Younger patients or those with an initial high hemoglobin count responded best to these drug regimens. Only 36% of our patients experienced severe marrow hypoplasia (i.e., a 75% or greater reduction in marrow cellularity) prior to complete remission, suggesting that cytosine arabinoside and 6-thioguanine in combination may selectively suppress leukemic cells while sparing normal hematopoietic elements. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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