| Autor: |
Zhao X; State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, P. R. China., Shen Y, Adogla EA, Viswanath A, Tan R, Benicewicz BC, Greytak AB, Lin Y, Wang Q |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of materials chemistry. B [J Mater Chem B] 2016 Apr 14; Vol. 4 (14), pp. 2421-2427. Date of Electronic Publication: 2016 Mar 17. |
| DOI: |
10.1039/c6tb00263c |
| Abstrakt: |
We report a general method for the preparation of quantum dot-labeled viruses through a strain-promoted azide-alkyne cycloaddition (SPAAC) reaction. The quantum dot sample was functionalized with methacrylate-based polymeric imidazole ligands (MA-PILs) bearing dibenzocyclooctyne groups. Enveloped measles virus was labeled with azide groups through the metabolic incorporation of a choline analogue into the host cell membrane, and then linked with the modified QDs. The virus retained its infectious ability against host cells after the modification with MA-PIL capped QDs. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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