Glomerular filtration rate determined by measuring serum clearance of a single dose of inulin and serum symmetric dimethylarginine concentration in clinically normal cheetahs ( Acinonyx jubatus ).
| Autor: | Sanchez CR, Hayek LC, Carlin EP, Brown SA, Citino S, Marker L, Jones KL, Murray S |
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| Jazyk: | angličtina |
| Zdroj: | American journal of veterinary research [Am J Vet Res] 2020 Apr; Vol. 81 (4), pp. 375-380. |
| DOI: | 10.2460/ajvr.81.4.375 |
| Abstrakt: | Objective: To establish a reference interval for glomerular filtration rate (GFR) determined by measuring serum clearance of a single IV dose of inulin in clinically normal cheetahs ( Acinonyx jubatus ) and compare serum symmetric dimethylarginine (SDMA) concentration in cheetahs with GFR. Animals: 33 cheetahs housed at 3 institutions. Procedures: A single bolus of inulin (3,000 mg/m 2 ) was administered IV, and 5 serial blood samples were collected and analyzed for serum inulin concentration with the anthrone technique. The GFR was estimated with a modified slope-intercept method for the slow component of the serum concentration-versus-time curve. Blood urea nitrogen and serum creatinine concentrations were measured in samples obtained immediately prior to inulin administration, and serum SDMA concentration was measured in stored samples. Results: Mean ± SD measured GFR was 1.58 ± 0.39 mL/min/kg, and the calculated reference interval was 0.84 to 2.37 mL/min/kg. There were significant negative correlations between GFR and serum creatinine concentration ( r = -0.499), BUN concentration ( r = -0.592), and age ( r = -0.463). Serum SDMA concentration was not significantly correlated with GFR ( r = 0.385), BUN concentration ( r = -0.281), or serum creatinine concentration ( r = 0.165). Conclusions and Clinical Relevance: A reference interval for GFR in clinically normal cheetahs was obtained. Further evaluation of animals with renal disease is needed to determine whether measuring serum clearance of a single IV dose of inulin is a reliable diagnostic test for early detection of renal disease in cheetahs. |
| Databáze: | MEDLINE |
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