Prospects for the creation of new antiviral drugs based on glycyrrhizic acid and its derivatives (a review).

Autor: Baltina LA; 1Institute of Organic Chemistry, UfaScientific Center, Russian Academy of Sciences, Ufa, Bashkortostan Russia., Kondratenko RM; 2Bashkir State Medical University, Ufa, Bashkortostan Russia., Baltina LA Jr; 1Institute of Organic Chemistry, UfaScientific Center, Russian Academy of Sciences, Ufa, Bashkortostan Russia., Plyasunova OA; 3State Research Center of Virology and Biotechnology Vector, Kol'tsovo, Novosibirsk Oblast Russia., Pokrovskii AG; 3State Research Center of Virology and Biotechnology Vector, Kol'tsovo, Novosibirsk Oblast Russia., Tolstikov GA; 1Institute of Organic Chemistry, UfaScientific Center, Russian Academy of Sciences, Ufa, Bashkortostan Russia.
Jazyk: angličtina
Zdroj: Pharmaceutical chemistry journal [Pharm Chem J] 2009; Vol. 43 (10), pp. 539-548. Date of Electronic Publication: 2010 Feb 04.
DOI: 10.1007/s11094-010-0348-2
Abstrakt: The review is devoted to the problem of creating new antiviral drugs based on glycyrrhizic acid (GA), the major triterpene glycoside extracted from roots of common and Ural licorice ( Glycyrrhiza glabra L. and G. uralensis Fisher, respectively). Published data on the natural GA sources, antiviral activity of GA and its derivatives, clinical applications of GA-based drugs, and the properties of GA-containing biologically active nutrient additives are summarized. Possible mechanisms of the antiviral activity of GA and its derivatives are examined. It is shown that chemical modification of GA is a promising way of designing new highly active antiviral drugs for the prophylaxis and treatment of HIV, hepatitis B and C, corona-virus, and herpes simplex virus infections.
(© Springer Science+Business Media, Inc. 2009.)
Databáze: MEDLINE
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