Secondary metabolites of Curvularia sp. G6-32, an endophyte of Sapindus saponaria , with antioxidant and anticholinesterasic properties.

Autor:	Polli AD; Departamento de Biotecnologia, Genética e Biologia Celular, Universidade Estadual de Maringá, Maringá, PR, Brazil., Ribeiro MADS; Departamento de Biotecnologia, Genética e Biologia Celular, Universidade Estadual de Maringá, Maringá, PR, Brazil., Garcia A; Departamento de Biotecnologia, Genética e Biologia Celular, Universidade Estadual de Maringá, Maringá, PR, Brazil., Polonio JC; Departamento de Biotecnologia, Genética e Biologia Celular, Universidade Estadual de Maringá, Maringá, PR, Brazil., Santos CM; Departamento de Biotecnologia, Genética e Biologia Celular, Universidade Estadual de Maringá, Maringá, PR, Brazil., Silva AA; Departamento de Biotecnologia, Genética e Biologia Celular, Universidade Estadual de Maringá, Maringá, PR, Brazil., Orlandelli RC; Departamento de Biotecnologia, Genética e Biologia Celular, Universidade Estadual de Maringá, Maringá, PR, Brazil., Castro JC; Departamento de Ciências Básicas da Saúde, Universidade Estadual de Maringá, Maringá, PR, Brazil., Abreu-Filho BA; Departamento de Ciências Básicas da Saúde, Universidade Estadual de Maringá, Maringá, PR, Brazil., Cabral MRP; Departamento de Química, Universidade Estadual de Maringá, Maringá, PR, Brazil., Sarragiotto MH; Departamento de Química, Universidade Estadual de Maringá, Maringá, PR, Brazil., Pamphile JA; Departamento de Biotecnologia, Genética e Biologia Celular, Universidade Estadual de Maringá, Maringá, PR, Brazil., Azevedo JL; Departamento de Genética, Escola Superior de Agricultura 'Luiz de Queiroz,' Universidade de São Paulo, Piracicaba, SP, Brazil.
Jazyk:	angličtina
Zdroj:	Natural product research [Nat Prod Res] 2021 Nov; Vol. 35 (21), pp. 4148-4153. Date of Electronic Publication: 2020 Mar 16.
DOI:	10.1080/14786419.2020.1739681
Abstrakt:	In the present study, the biological activity of an extract of the secondary metabolites (E-G6-32) produced by the Curvularia sp. G6-32 endophyte (isolated from the medicinal plant Sapindus saponaria L.) was investigated. The antioxidant potential was confirmed by the DPPH (22.5%) and ABTS (62.7%) assays, and the total phenolic compound content was 40 µg gallic acid equivalents/mg. The extract E-G6-32 displayed good inhibitory activity toward butyrylcholinesterase (BuChE; IC 50 = 110 ± 0.05 µg mL -1 ). The extract E-G6-32 was subjected to spectroscopic and mass spectrometry analyses. Comparison with the literature data confirmed that (-)-asperpentyn ( 1 ) was a major component. Asperpentyn belongs to the epoxyquinone family, which has attractive structural complexity, diverse functional groups, and a broad range of biological activities, including specific enzyme inhibitory activity. Our results suggest that Curvularia sp. G6-32 is a promising source of bioactive secondary metabolites and contains (-)-asperpentyn, which has potential pharmaceutical interest.[Figure: see text].
Databáze:	MEDLINE
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