Intravoxel incoherent motion parameters in the evaluation of chronic hepatitis B virus-induced hepatic injury: fibrosis and capillarity changes.

Autor: Gulbay M; Department of Radiology, Ankara Numune Education and Research Hospital, Ankara, Turkey. mutlu.gulbay@saglik.gov.tr.; Ankara Sehir Hastanesi Radyoloji Klinigi, 06800, Universiteler Mah Bilkent Blv No:1, Ankara, Turkey. mutlu.gulbay@saglik.gov.tr., Ciliz DS; Department of Radiology, Ankara Numune Education and Research Hospital, Ankara, Turkey., Celikbas AK; Department of Clinical Microbiology and Infectious Diseases, Ankara Numune Education and Research Hospital, Ankara, Turkey., Ocalan DT; Department of Pathology, Ankara Numune Education and Research Hospital, Ankara, Turkey., Sayin B; Department of Radiology, Ankara Numune Education and Research Hospital, Ankara, Turkey., Ozbay BO; Department of Clinical Microbiology and Infectious Diseases, Ankara Numune Education and Research Hospital, Ankara, Turkey., Alp E; Department of Radiology, Ankara Numune Education and Research Hospital, Ankara, Turkey.
Jazyk: angličtina
Zdroj: Abdominal radiology (New York) [Abdom Radiol (NY)] 2020 Aug; Vol. 45 (8), pp. 2345-2357.
DOI: 10.1007/s00261-020-02430-9
Abstrakt: Objective: To evaluate the diagnostic efficacy of intravoxel incoherent motion (IVIM) parameters in hepatitis B virus (HBV)-induced hepatic fibrosis using different calculation methods and to investigate histopathologic origins.
Materials and Methods: Liver biopsies from 37 prospectively recruited chronic hepatitis B patients were obtained. Twelve b-value (0-1000 s/mm 2 ) diffusion-weighted imaging (DWI) was performed with a 1.5 T scanner and was followed by blinded percutaneous liver biopsy. All biopsy specimens were evaluated with Ishak staging, and the microvascular density (MVD) was calculated. Patients were classified as having no/mild (F0-1), moderate (F2-3), or marked (F4-5) fibrosis. Pseudodiffusion (D*), the perfusion fraction (f), and the apparent diffusion coefficient (ADC) were calculated using all b-values, while true diffusion (D) was calculated using all b-values [D 0-1000 ] and b-values greater than 200 s/mm 2 [D 200 - 1000 ]. Three concentric regions of interest (ROIs) (5, 10, and 20 mm) centered on the biopsy site were used.
Results: D* was correlated with the MVD (p = 0.015, Pearson's r = 0.415), but f was not (p = 0.119). D 0-1000 was inversely correlated with Ishak stage (p = 0.000, Spearman's r s  =  - 0.685) and was significantly decreased in all the fibrosis groups; however, only the no/mild and marked fibrosis groups had significantly different D 200-1000 values. A pairwise comparison of receiver operating characteristic (ROC) curves of D 0-1000 and D 200-1000 showed significant differences (p = 0.039). D* was the best at discriminating early fibrosis (AUC = 0.861), while the ADC best discriminated advanced fibrosis (AUC = 0.964).
Conclusion: D* was correlated with the MVD and is a powerful parameter to discriminate early hepatic fibrosis. D significantly decreased with advanced fibrosis stage when using b-values less than 200 s/mm 2 in calculations.
Databáze: MEDLINE
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