A therapeutic effect of Nigella sativa extract on female Wistar rats vulvovaginal candidiasis model.

Autor:	Rusda M; Obstetrics and Gynaecology Department, Universitas Sumatera Utara, Indonesia., Ganis Siregar MF; Obstetrics and Gynaecology Department, Universitas Sumatera Utara, Indonesia., Lelo A; Pharmacology Department, School of Medicine, Universitas Sumatera Utara, Indonesia., Ilyas S; Department of Biology, Faculty of Mathematics and Natural Sciences, Universitas Sumatera Utara, Indonesia., Akbari Ganie R; Clinical Pathology Department, School of Medicine, Universitas Sumatera Utara, Indonesia., Effendi Y; Obstetrics and Gynaecology Department, School of Medicine, Universitas Sriwijaya, Indonesia., Zaitun Hasibuan PA; Faculty of Pharmacy, Universitas Sumatera Utara, Indonesia., Lia Iswara RR; Microbiology Department, School of Medicine, Universitas Sumatera Utara, Indonesia.
Jazyk:	angličtina
Zdroj:	Medicinski glasnik : official publication of the Medical Association of Zenica-Doboj Canton, Bosnia and Herzegovina [Med Glas (Zenica)] 2020 Aug 01; Vol. 17 (2), pp. 472-476.
DOI:	10.17392/1112-20
Abstrakt:	Aim Vulvovaginal candidiasis (VVC) is a disease mostly caused by Candida albicans and affects the quality of life of women especially in the form of chronic recurrent vulvovaginal candidiasis(RVVC). Nigella sativa is known to have several effects such as antimicrobial, anti-inflammatory, immune stimulation and anticancer properties. The aim of this study was to evaluate the effect of Nigella sativa on vulvovaginal candidiasis. Methods This study is a true experimental design, we used 28 Wistar strain rats divided into 4 groups, all groups were conditioned in a pseudoestrus state. Candida albicans was inoculated into the rats' vagina for 3 consecutive days. All groups were observed every 24 hours, 48 hours and 72 hours to evaluate the number of Candida albicans colonies, IgG and IgM anti Candida. Results After administration of intervention, there was a significant difference in the amount of fungal colonization after the treatment in each group (p<0.001). There was no significant difference in the effectiveness of Nigella sativa and fluconazole in supressing Candida albicans colonies after 72 hours (p=0.101). The administration of Nigella sativa showed a significant difference in the increase in IgM levels compared to the others group (p<0.001), while the IgG level did not show a significant difference (p=0.423). Conclusion Nigella sativa provides a therapeutic effect by decreasing the number of fungal colonies and increasing IgM levels. (Copyright© by the Medical Assotiation of Zenica-Doboj Canton.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu