SARI prevents ocular angiogenesis and inflammation in mice.

Autor: Zhang W; Department of Ophthalmology, West China Hospital, Sichuan University, Chengdu, China.; Research Laboratory of Ophthalmology and Vision Sciences, West China Hospital, Sichuan University, Chengdu, China.; Department of Optometry and Visual Science, West China Hospital, Sichuan University, Chengdu, China., Dai L; State Key Laboratory of Biotherapy/Collaborative Innovation Center for Biotherapy, West China Hospital, Sichuan University, Chengdu, China., Li X; Department of Ophthalmology, West China Hospital, Sichuan University, Chengdu, China.; Research Laboratory of Ophthalmology and Vision Sciences, West China Hospital, Sichuan University, Chengdu, China., Li Y; State Key Laboratory of Biotherapy/Collaborative Innovation Center for Biotherapy, West China Hospital, Sichuan University, Chengdu, China., Hung Yap MK; School of Optometry, The Hong Kong Polytechnic University, Hong Kong, China., Liu L; Department of Ophthalmology, West China Hospital, Sichuan University, Chengdu, China.; Department of Optometry and Visual Science, West China Hospital, Sichuan University, Chengdu, China., Deng H; State Key Laboratory of Biotherapy/Collaborative Innovation Center for Biotherapy, West China Hospital, Sichuan University, Chengdu, China.
Jazyk: angličtina
Zdroj: Journal of cellular and molecular medicine [J Cell Mol Med] 2020 Apr; Vol. 24 (7), pp. 4341-4349. Date of Electronic Publication: 2020 Mar 02.
DOI: 10.1111/jcmm.15096
Abstrakt: SARI (Suppressor of AP-1, regulated by IFN-β) is known to play an important role in some systemic disease processes such an inflammatory conditions and cancer. We hypothesize that SARI may also play a role in ocular diseases involving inflammation and neovascularization. To explore our hypothesis, further, we investigated an endotoxin-induced uveitis (EIU) and experimental argon laser-induced choroidal neovascularization (CNV) model in SARI wild-type (SARI WT ) and SARI-deficient (SARI -/- ) mice. Through imaging, morphological and immunohistochemical (IHC) studies, we found that SARI deficiency exacerbated the growth of CNV. More VEGF-positive cells were presented in the retina of SARI -/- mice with CNV. Compared to SARI WT  mice, more inflammatory cells infiltrated the ocular anterior segment and posterior segments in SARI -/- mice with EIU. Collectively, the results point to a potential dual functional role of SARI in inflammatory ocular diseases, suggesting that SARI could be a potential therapy target for ocular inflammation and neovascularization.
(© 2020 The Authors. Journal of Cellular and Molecular Medicine published by Foundation for Cellular and Molecular Medicine and John Wiley & Sons Ltd.)
Databáze: MEDLINE
Externí odkaz: