Neuroprotective effects of quercetin on cerebral vasospasm following experimental subarachnoid haemorrhage in rats

Autor: Gül Ş; Department of Neurosurgery, Faculty of Medicine, Bülent Ecevit University, Zonguldak, Turkey, Aydoğmuş E; Department of Neurosurgery, Kartal Dr. Lütfi Kırdar Training and Research Hospital, İstanbul, Turkey, Bahadir B; Department of Pathology, Faculty of Medicine, Bülent Ecevit University, Zonguldak, Turkey, Büyükuysal MÇ; Department of Biostatistics, Faculty of Medicine, Bülent Ecevit University, Zonguldak, Turkey, Güven B; Department of Biochemistry, Faculty of Medicine, Bülent Ecevit University, Zonguldak, Turkey
Jazyk: angličtina
Zdroj: Turkish journal of medical sciences [Turk J Med Sci] 2020 Jun 23; Vol. 50 (4), pp. 1106-1110. Date of Electronic Publication: 2020 Jun 23.
DOI: 10.3906/sag-1904-207
Abstrakt: Background/aim: We examined the protective effects of the natural flavonoid, quercetin, against cerebral vasospasm in an experimental rat subarachnoid haemorrhage (SAH) model.
Materials and Methods: Thirty-eight albino Wistar rats were divided into five groups as follows: group 1 (G1, n=8), no experimental intervention; group 2 (G2, n=8), subarachnoid physiological saline; group 3 (G3, n=8), SAH; group 4 (G4, n=7) SAH and low-dose (10 mg/kg) quercetin treatment; group 5 (G5, n=7), SAH and high-dose (50 mg/kg) quercetin treatment. Subarachnoid haemorrhage was induced by injection of 0.15 cc of autologous blood taken from the tail artery into the cisterna magna from the craniocervical junction and basilar arteries and blood samples were taken for biochemical and histopathological analyses.
Results: Malondialdehyde (MDA) levels were significantly higher in G2 and G3 than in G1 (P < 0.05). Significant decreases in MDA were observed in G4 and G5 compared with G2 (P < 0.05, G4–G2; P < 0.05, G5–G2). There were no significant differences between G2 and G3 or among G1, G4, and G5. No statistically significant differences were found in total antioxidant capacity between the groups (P > 0.05). There were no significant differences in basilar artery (BA) wall thickness between G3 and G4 or between G3 and G5, but G4 and G5 showed greater luminal diameters than G3 (P < 0.05). There were no significant differences in BA thickness or luminal diameter between G4 and G5.
Conclusion: Our results suggested that quercetin may be beneficial in SAH therapy by preventing vasospasm.
Competing Interests: The authors certify that they have NO affiliations with or involvement in any organization or entity with any financial interest (such as honoraria; educational grants; participation in speakers’ bureaus; membership, employment, consultancies, stock ownership, or other equity interest; and expert testimony or patent-licensing arrangements), or nonfinancial interest (such as personal or professional relationships, affiliations, knowledge or beliefs) in the subject matter or materials discussed in this manuscript “Neuroprotective effects of quercetin on cerebral vasospasm following experimental subarachnoid haemorrhage in rats”.
(This work is licensed under a Creative Commons Attribution 4.0 International License.)
Databáze: MEDLINE
Externí odkaz: