Diabetic nephropathy execrates epithelial-to-mesenchymal transition (EMT) via miR-2467-3p/Twist1 pathway.

Autor: Xu Y; Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fujian Medical University, Fuzhou, 350004, China., Ouyang C; Hubei Key Laboratory of Cardiovascular, Cerebrovascular and Metabolic Disorders, Hubei University of Science and Technology, Xianning, 437100, China., Lyu D; Key Laboratory of Cardiovascular and Cerebrovascular Medicine, School of Pharmacy, Nanjing Medical University, Nanjing, 211166, China., Lin Z; School of Clinical Medicine, Fujian Medical University, Fuzhou, 350004, China., Zheng W; School of Clinical Medicine, Fujian Medical University, Fuzhou, 350004, China., Xiao F; School of Clinical Medicine, Fujian Medical University, Fuzhou, 350004, China., Xu Z; School of Clinical Medicine, Fujian Medical University, Fuzhou, 350004, China., Ding L; Department of Ophthalmology, Xiangya Hospital, Central South University, Changsha, 410008, China. Electronic address: lexiding@csu.edu.cn.
Jazyk: angličtina
Zdroj: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2020 May; Vol. 125, pp. 109920. Date of Electronic Publication: 2020 Feb 09.
DOI: 10.1016/j.biopha.2020.109920
Abstrakt: Although diabetic nephropathy (DN) is induced by a complicate interplay of multiple factors, the underlying mechanisms remain poorly characterized, even the treatment. Herein, we show that both of DN patients and STZ-induced type 1 diabetic rat exhibit the reduction both of urinary and circulating miR-2467-3p. We identify a negative correlation between miR-2467-3p levels and renal dysfunction. Administration of miR-2467-3p prevents diabetes-induced renal dysfunction and represses renal fibrosis in STZ-induced type 1 diabetic rats. Conversely, anti-miR-2467 overexpression exacerbates renal dysfunction and fibrosis in STZ-induced rats. In diabetic condition, the reduction of miR-2467-3p promotes expression of Twist1, inducing epithelial-to-mesenchymal transition (EMT), resulting in renal fibrosis and kidney dysfunction. Together, our study presents miR-2467/Twist1/EMT as a regulatory axis of renal dysfunction in DN.
Competing Interests: Declaration of Competing Interest None.
(Copyright © 2020. Published by Elsevier Masson SAS.)
Databáze: MEDLINE
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