Recent updates on true potential of an anesthetic agent as a regulator of cell signaling pathways and non-coding RNAs in different cancers: Focusing on the brighter side of propofol.

Autor: Farooqi AA; Institute of Biomedical and Genetic Engineering (IBGE), Islamabad, Pakistan. Electronic address: ammadfarooqi@rlmclahore.com., Adylova A; Department of Postgraduate Education and Research, Kazakhstan Medical University KSPH, Almaty, Kazakhstan., Sabitaliyevich UY; Department of Postgraduate Education and Research, Kazakhstan Medical University KSPH, Almaty, Kazakhstan., Attar R; Department of Obstetrics and Gynecology, Yeditepe University, Turkey., Sohail MI; Department of Zoology, GCU Lahore, Pakistan., Yilmaz S; Department of Anatomy, Yozgat Bozok University Faculty of Medicine, Yozgat, Turkey.
Jazyk: angličtina
Zdroj: Gene [Gene] 2020 May 05; Vol. 737, pp. 144452. Date of Electronic Publication: 2020 Feb 07.
DOI: 10.1016/j.gene.2020.144452
Abstrakt: There has always been a quest to search for synthetic and natural compounds having premium pharmacological properties and minimum off-target and/or side effects. Therefore, in accordance with this approach, scientists have given special attention to the molecules having remarkable ability to target oncogenic protein network, restore drug sensitivity and induce apoptosis in cancer cells. The mechanisms through which general anesthetics modulated wide-ranging deregulated cell signaling pathways and non-coding RNAs remained unclear. However, rapidly accumulating experimentally verified evidence has started to resolve this long-standing mystery and a knowledge about these important molecular targets has surfaced and how these drugs act at the molecular level is becoming more understandable. In this review we have given special attention to available evidence related to ability of propofol to modulate Wnt/β-catenin, JAK/STAT and mTOR-driven pathway. Excitingly, great strides have been made in sharpening our concepts related to potential of propofol to modulate non-coding RNAs in different cancers. Collectively, these latest findings offer interesting, unexplored opportunities to target deregulated signaling pathways to induce apoptosis in drug-resistant cancers.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2020 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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