Invasive breast cancer: Current perspectives and emerging views.

Autor: Shea EKH; Department of Clinical Pathology, Tuen Mun Hospital, Tuen Mun, Hong Kong.; Department of Anatomical Pathology, Singapore General Hospital, Singapore, Singapore., Koh VCY; Department of Anatomical Pathology, Singapore General Hospital, Singapore, Singapore., Tan PH; Division of Pathology, Singapore General Hospital, Singapore, Singapore.
Jazyk: angličtina
Zdroj: Pathology international [Pathol Int] 2020 May; Vol. 70 (5), pp. 242-252. Date of Electronic Publication: 2020 Feb 10.
DOI: 10.1111/pin.12910
Abstrakt: Invasive breast cancer constitutes a heterogeneous group of tumors. They comprise various histological types that differ in clinical presentation, imaging features, histopathological characteristics, biomarker profiles, prognostic and predictive parameters. The current classification of invasive breast cancer is based primarily on histopathological features. Invasive carcinoma of no special type accounts for the majority, with some rare entities also being described. With recent research and advances, there are emerging concepts, including new genetic insights of invasive breast cancer and the role of the stromal microenvironment. With greater understanding of the pathogenesis of invasive breast cancer, changes based on the correlation of histologic and genetic findings have been incorporated in the latest World Health Organization classification of breast tumors. Medullary carcinomas are subsumed as invasive carcinoma of no special type with basal-like and medullary features, regarded as part of the spectrum of tumor infiltrating lymphocyte-rich breast cancers. Tall cell carcinoma with reversed polarity is proposed as a distinct entity in recognition of unique IDH2 mutations. This article reviews conventional prognostic parameters, new histological entities, and updates on breast cancer classification, with inclusion of some genetic insights into breast cancer and the role of tumor infiltrating lymphocytes.
(© 2020 Japanese Society of Pathology and John Wiley & Sons Australia, Ltd.)
Databáze: MEDLINE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje