The Susceptibility of Human Melanoma Cells to Infection with the Leningrad-16 Vaccine Strain of Measles Virus.

Autor: Ammour Y; I.I. Mechnikov Research Institute for Vaccines and Sera, 105064 Moscow, Russia., Ryabaya O; N.N. Blokhin National Medical Research Center of Oncology of the Ministry of Health of the Russian Federation, 115478, Moscow, Russia., Shchetinina Y; I.I. Mechnikov Research Institute for Vaccines and Sera, 105064 Moscow, Russia., Prokofeva E; I.I. Mechnikov Research Institute for Vaccines and Sera, 105064 Moscow, Russia., Gavrilova M; I.I. Mechnikov Research Institute for Vaccines and Sera, 105064 Moscow, Russia., Khochenkov D; N.N. Blokhin National Medical Research Center of Oncology of the Ministry of Health of the Russian Federation, 115478, Moscow, Russia.; Medicinal Chemistry Center, Togliatti State University, 445020 Togliatti, Russia., Vorobyev D; I.I. Mechnikov Research Institute for Vaccines and Sera, 105064 Moscow, Russia.; I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation, 119146 Moscow, Russia., Faizuloev E; I.I. Mechnikov Research Institute for Vaccines and Sera, 105064 Moscow, Russia., Shohin I; I.I. Mechnikov Research Institute for Vaccines and Sera, 105064 Moscow, Russia.; Institute of biochemical technology and nanotechnology, RUDN University, 117198 Moscow, Russia., Zverev VV; I.I. Mechnikov Research Institute for Vaccines and Sera, 105064 Moscow, Russia.; I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation, 119146 Moscow, Russia., Svitich O; I.I. Mechnikov Research Institute for Vaccines and Sera, 105064 Moscow, Russia.; I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation, 119146 Moscow, Russia., Nasedkina T; Engelhardt Institute of Molecular Biology of the Russian Academy of Sciences, 119991 Moscow, Russia.
Jazyk: angličtina
Zdroj: Viruses [Viruses] 2020 Feb 04; Vol. 12 (2). Date of Electronic Publication: 2020 Feb 04.
DOI: 10.3390/v12020173
Abstrakt: Oncolytic viruses, including live attenuated measles virus (MV) vaccine strains, have recently been shown as promising therapeutic agents against human malignancies. In this study, the oncolytic potential of the attenuated vaccine strain Leningrad-16 (L-16) of MV was evaluated in a panel of human metastatic melanoma cell lines. The L-16 measles virus was shown to replicate within melanoma cells mediating direct cell killing of tumor cells, although all melanoma cell lines varied in regard to their ability to respond to L-16 MV infection, as revealed by the different pattern of the Interferon Stimulated Gene expression, cytokine release and mechanisms of cell death. Furthermore, the statistically significant L-16 measles virus related tumor growth inhibition was demonstrated in a melanoma xenograft model. Therefore, L-16 MV represents an appealing oncolytic platform for target delivery of therapeutic genes along with other attenuated measles virus strains.
Competing Interests: The authors declare no conflict of interest.
Databáze: MEDLINE
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