| Autor: |
Mertschnigg T; Institute of Hygiene, Microbiology and Environmental Medicine, Medical University of Graz, Graz, Austria., Patz S; Algorithms in Bioinformatics, Center for Bioinformatics, University of Tübingen, Tübingen, Germany., Becker M; Institute for National and International Plant Health, Julius Kühn Institute, Federal Research Centre for Cultivated Plants, Braunschweig, Germany., Feierl G; Institute of Hygiene, Microbiology and Environmental Medicine, Medical University of Graz, Graz, Austria., Ruppel S; Leibniz Institute of Vegetable and Ornamental Crops, Grossbeeren, Germany., Bunk B; Leibniz Institute DSMZ-German Collection of Microorganisms and Cell Cultures, Braunschweig, Germany., Spröer C; Leibniz Institute DSMZ-German Collection of Microorganisms and Cell Cultures, Braunschweig, Germany., Overmann J; Leibniz Institute DSMZ-German Collection of Microorganisms and Cell Cultures, Braunschweig, Germany.; Microbiology, Braunschweig University of Technology, Braunschweig, Germany., Zarfel G; Institute of Hygiene, Microbiology and Environmental Medicine, Medical University of Graz, Graz, Austria. gernot.zarfel@medunigraz.at. |
| Abstrakt: |
Kosakonia radicincitans is a species within the new genus Kosakonia. Many strains of this genus have been isolated from plants, but some strains are assumed to act as facultative human pathogens. In this study, an in-depth analysis of a Kosakonia isolate from human blood was performed. The strain was originally isolated from blood and identified as a member of the Enterobacter cloacae complex, exhibiting an atypical result in susceptibility testing. Therefore, the genetic background was examined, including phylogenetic classification and screening for virulence factors. Using whole-genome sequencing, the isolate was identified as a K. radicincitans strain, revealing a virulence gene cluster for yersiniabactin biosynthesis in contrast to all other strains of the species. Whole-genome sequencing was the perfect method for identifying putative virulence factors of a particular Kosakonia strain and will help distinguish beneficial strains from pathogenic strains in the future. To our knowledge, this is the first report of Kosakonia-related bacteraemia from Europe. |
