Therapeutic Potential of Biochanin-A Against Isoproterenol-Induced Myocardial Infarction in Rats.

Autor:	Govindasami S; Department of Biochemistry, Vellalar College For Women, Thindal, Erode, Tamil Nadu-638012, India., Uddandrao VVS; Centre for Biological Sciences, Department of Biochemistry, K.S. Rangasamy College of Arts and Science, Tiruchengode, Namakkal District, Tamilnadu-637215, India., Raveendran N; Centre for Biological Sciences, Department of Biochemistry, K.S. Rangasamy College of Arts and Science, Tiruchengode, Namakkal District, Tamilnadu-637215, India., Sasikumar V; Centre for Biological Sciences, Department of Biochemistry, K.S. Rangasamy College of Arts and Science, Tiruchengode, Namakkal District, Tamilnadu-637215, India.
Jazyk:	angličtina
Zdroj:	Cardiovascular & hematological agents in medicinal chemistry [Cardiovasc Hematol Agents Med Chem] 2020; Vol. 18 (1), pp. 31-36.
DOI:	10.2174/1871525718666200206114304
Abstrakt:	Background: This study determined the effect of Biochanin A (BCA) on isoproterenol (ISO) induced Myocardial Infarction (MI) in male Wistar rats. Methods: Animals (weighing 150-180 g) were divided into four groups, with six animals in each group and pretreated with BCA (10mg/kg Body Weight [BW]) and ɑ-tocopherol (60mg/kg BW) for 30 days; and ISO (20mg/kg BW) was administrated subcutaneously on the 31st and 32nd day. Results: ISO-induced MI rats demonstrated the significant elevation of serum glutamic oxaloacetic transaminase, serum glutamic pyruvic transaminase, lactate dehydrogenase, creatine kinase-MB and cardiac troponin; however, concomitant pretreatment with BCA protected the rats from cardiotoxicity caused by ISO. Activities of antioxidant enzymes, such as superoxide dismutase, catalase, glutathione peroxidase, glutathione-S-transferase and glutathione reductase significantly reduced in the heart with ISO-induced MI. Pretreatment with BCA produced a marked reversal of these antioxidant enzymes related to MI-induced by ISO. Conclusion: In conclusion, this study suggested that BCA exerts cardioprotective effects through modulating lipid peroxidation, enhancing antioxidants, and detoxifying enzyme systems. (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.)
Databáze:	MEDLINE
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