The Rapid Regenerative Response of a Model Sea Anemone Species Exaiptasia pallida Is Characterised by Tissue Plasticity and Highly Coordinated Cell Communication.

Autor: van der Burg CA; School of Biomedical Sciences, Faculty of Health, Queensland University of Technology, Brisbane, QLD, 4000, Australia. chloe.vanderburg@hdr.qut.edu.au.; Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, QLD, 4059, Australia. chloe.vanderburg@hdr.qut.edu.au., Pavasovic A; School of Biomedical Sciences, Faculty of Health, Queensland University of Technology, Brisbane, QLD, 4000, Australia.; Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, QLD, 4059, Australia., Gilding EK; Institute for Molecular Bioscience, University of Queensland, Brisbane, QLD, 4067, Australia., Pelzer ES; School of Biomedical Sciences, Faculty of Health, Queensland University of Technology, Brisbane, QLD, 4000, Australia.; Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, QLD, 4059, Australia., Surm JM; Department of Ecology, Evolution and Behavior, Alexander Silberman Institute of Life Sciences, The Hebrew University of Jerusalem, 9190401, Jerusalem, Israel., Smith HL; Earth, Environment and Biological Sciences, Science and Engineering Faculty, Queensland University of Technology, Brisbane, QLD, 4000, Australia.; Institute for Future Environments, Science and Engineering Faculty, Queensland University of Technology, Brisbane, QLD, 4000, Australia., Walsh TP; School of Biomedical Sciences, Faculty of Health, Queensland University of Technology, Brisbane, QLD, 4000, Australia.; Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, QLD, 4059, Australia., Prentis PJ; Earth, Environment and Biological Sciences, Science and Engineering Faculty, Queensland University of Technology, Brisbane, QLD, 4000, Australia.; Institute for Future Environments, Science and Engineering Faculty, Queensland University of Technology, Brisbane, QLD, 4000, Australia.
Jazyk: angličtina
Zdroj: Marine biotechnology (New York, N.Y.) [Mar Biotechnol (NY)] 2020 Apr; Vol. 22 (2), pp. 285-307. Date of Electronic Publication: 2020 Feb 03.
DOI: 10.1007/s10126-020-09951-w
Abstrakt: Regeneration of a limb or tissue can be achieved through multiple different pathways and mechanisms. The sea anemone Exaiptasia pallida has been observed to have excellent regenerative proficiency, but this has not yet been described transcriptionally. In this study, we examined the genetic expression changes during a regenerative timecourse and reported key genes involved in regeneration and wound healing. We found that the major response was an early (within the first 8 h) upregulation of genes involved in cellular movement and cell communication, which likely contribute to a high level of tissue plasticity resulting in the rapid regeneration response observed in this species. We find the immune system was only transcriptionally active in the first 8 h post-amputation and conclude, in accordance with previous literature, that the immune system and regeneration have an inverse relationship. Fifty-nine genes (3.8% of total) differentially expressed during regeneration were identified as having no orthologues in other species, indicating that regeneration in E. pallida may rely on the activation of species-specific novel genes. Additionally, taxonomically restricted novel genes, including species-specific novels, and highly conserved genes were identified throughout the regenerative timecourse, showing that both may work in concert to achieve complete regeneration.
Databáze: MEDLINE
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