Reevaluating the Role of Persistent Neural Activity in Short-Term Memory.

Autor: Masse NY; Department of Neurobiology, The University of Chicago, Chicago, IL, USA. Electronic address: nicolas.masse@gmail.com., Rosen MC; Department of Neurobiology, The University of Chicago, Chicago, IL, USA., Freedman DJ; Department of Neurobiology, The University of Chicago, Chicago, IL, USA; Grossman Institute for Neuroscience, Quantitative Biology and Human Behavior, The University of Chicago, Chicago, IL, USA. Electronic address: dfreedman@uchicago.edu.
Jazyk: angličtina
Zdroj: Trends in cognitive sciences [Trends Cogn Sci] 2020 Mar; Vol. 24 (3), pp. 242-258. Date of Electronic Publication: 2020 Jan 29.
DOI: 10.1016/j.tics.2019.12.014
Abstrakt: A traditional view of short-term working memory (STM) is that task-relevant information is maintained 'online' in persistent spiking activity. However, recent experimental and modeling studies have begun to question this long-held belief. In this review, we discuss new evidence demonstrating that information can be 'silently' maintained via short-term synaptic plasticity (STSP) without the need for persistent activity. We discuss how the neural mechanisms underlying STM are inextricably linked with the cognitive demands of the task, such that the passive maintenance and the active manipulation of information are subserved differently in the brain. Together, these recent findings point towards a more nuanced view of STM in which multiple substrates work in concert to support our ability to temporarily maintain and manipulate information.
(Copyright © 2020 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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