Retinal inputs signal astrocytes to recruit interneurons into visual thalamus.

Autor:	Su J; Center for Neurobiology Research, Fralin Biomedical Research Institute at Virginia Tech Carilion, Roanoke, VA 24016., Charalambakis NE; Department of Anatomical Sciences and Neurobiology, University of Louisville School of Medicine, Louisville, KY 40202., Sabbagh U; Center for Neurobiology Research, Fralin Biomedical Research Institute at Virginia Tech Carilion, Roanoke, VA 24016.; Graduate Program in Translational Biology, Medicine, and Health, Virginia Tech, Blacksburg, VA 24061., Somaiya RD; Center for Neurobiology Research, Fralin Biomedical Research Institute at Virginia Tech Carilion, Roanoke, VA 24016.; Graduate Program in Translational Biology, Medicine, and Health, Virginia Tech, Blacksburg, VA 24061., Monavarfeshani A; Center for Neurobiology Research, Fralin Biomedical Research Institute at Virginia Tech Carilion, Roanoke, VA 24016.; Department of Biological Sciences, Virginia Tech, Blacksburg, VA 24061., Guido W; Department of Anatomical Sciences and Neurobiology, University of Louisville School of Medicine, Louisville, KY 40202; william.guido@louisville.edu mafox1@vtc.vt.edu., Fox MA; Center for Neurobiology Research, Fralin Biomedical Research Institute at Virginia Tech Carilion, Roanoke, VA 24016; william.guido@louisville.edu mafox1@vtc.vt.edu.; Department of Biological Sciences, Virginia Tech, Blacksburg, VA 24061.; Department of Pediatrics, Virginia Tech Carilion School of Medicine, Roanoke, VA 24016.
Jazyk:	angličtina
Zdroj:	Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Feb 04; Vol. 117 (5), pp. 2671-2682. Date of Electronic Publication: 2020 Jan 21.
DOI:	10.1073/pnas.1913053117
Abstrakt:	Inhibitory interneurons comprise a fraction of the total neurons in the visual thalamus but are essential for sharpening receptive field properties and improving contrast-gain of retinogeniculate transmission. During early development, these interneurons undergo long-range migration from germinal zones, a process regulated by the innervation of the visual thalamus by retinal ganglion cells. Here, using transcriptomic approaches, we identified a motogenic cue, fibroblast growth factor 15 (FGF15), whose expression in the visual thalamus is regulated by retinal input. Targeted deletion of functional FGF15 in mice led to a reduction in thalamic GABAergic interneurons similar to that observed in the absence of retinal input. This loss may be attributed, at least in part, to misrouting of interneurons into nonvisual thalamic nuclei. Unexpectedly, expression analysis revealed that FGF15 is generated by thalamic astrocytes and not retino-recipient neurons. Thus, these data show that retinal inputs signal through astrocytes to direct the long-range recruitment of interneurons into the visual thalamus. Competing Interests: The authors declare no competing interest. (Copyright © 2020 the Author(s). Published by PNAS.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu