Virus-induced transposable element expression up-regulation in human and mouse host cells.

Autor:	Macchietto MG; Institute for Health Informatics, University of Minnesota, Minneapolis, MN, USA., Langlois RA; Biochemistry, Molecular Biology and Biophysics Graduate Program, University of Minnesota, Minneapolis, MN, USA., Shen SS; Institute for Health Informatics, University of Minnesota, Minneapolis, MN, USA shens@umn.edu.; Clinical Translational Science Institute, University of Minnesota, Minneapolis, MN, USA.
Jazyk:	angličtina
Zdroj:	Life science alliance [Life Sci Alliance] 2020 Jan 21; Vol. 3 (2). Date of Electronic Publication: 2020 Jan 21 (Print Publication: 2020).
DOI:	10.26508/lsa.201900536
Abstrakt:	Virus-host cell interactions initiate a host cell-defensive response during virus infection. How transposable elements in the host cell respond to viral stress at the molecular level remains largely unclear. By reanalyzing next generation sequencing data sets from dozens of virus infection studies from the Gene Expression Omnibus database, we found that genome-wide transposon expression up-regulation in host cells occurs near antiviral response genes and exists in all studies regardless of virus, species, and host cell tissue types. Some transposons were found to be up-regulated almost immediately upon infection and before increases in virus replication and significant increases in interferon β expression. These findings indicate that transposon up-regulation is a common phenomenon during virus infection in human and mouse and that early up-regulated transposons are part of the first wave response during virus infection. (© 2020 Macchietto et al.)
Databáze:	MEDLINE
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