Luminescent Silver-Purine Double Helicate: Synthesis, Self-Assembly and Antibacterial Action.

Autor: Venkatesh V; Department of Chemistry, Center for Environmental Science and Engineering, Indian Institute of Technology Kanpur, Kanpur, 208016, UP, India.; Department of Chemistry, University of Warwick, Coventry, CV4 7AL, UK., Kumaran MDB; Centre for Advanced Studies in Botany, Guindy Campus, University of Madras, Chennai, 600025, TN, India.; Deapartment of Biotechnology, D. G. Vaishnav College, Chennai, 600106, TN, India., Saravanan RK; Department of Chemistry, Center for Environmental Science and Engineering, Indian Institute of Technology Kanpur, Kanpur, 208016, UP, India., Kalaichelvan PT; Centre for Advanced Studies in Botany, Guindy Campus, University of Madras, Chennai, 600025, TN, India., Verma S; Department of Chemistry, Center for Environmental Science and Engineering, Indian Institute of Technology Kanpur, Kanpur, 208016, UP, India.
Jazyk: angličtina
Zdroj: ChemPlusChem [Chempluschem] 2016 Dec; Vol. 81 (12), pp. 1266-1271. Date of Electronic Publication: 2016 Aug 03.
DOI: 10.1002/cplu.201600293
Abstrakt: The synthesis, self-assembly and antibacterial activity of a luminescent silver-purine double helicate is reported. The structure of the newly synthesized silver-supported helicate [C 36 H 24 N 16 O 4 Cl 5 Ag 1 ] was unambiguously characterized by single-crystal X-ray crystallography. It exhibited a bright bluish-green emission (λ max =460 nm), when excited with 380 nm light. Microscopic investigations showed that the complex has a propensity to self-assemble into nanospheres. The antibacterial activity of this silver-containing helicate was studied against both Gram-positive and Gram-negative bacteria. MIC (minimal inhibitory concentration) values showed that the complex is very active against Gram-negative bacteria. Further internalization of the silver complex into E. coli bacteria was mapped with the help of microscopic techniques. These results are significant as silver was recently found to enhance antibiotic action against Gram-negative bacteria, raising hope in countering severe bacterial infections.
(© 2016 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.)
Databáze: MEDLINE
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