| Autor: |
Akosung E; Faculty of Sciences, Chemistry Laboratory, University of Douala, Douala, Cameroon.; H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences (ICCBS) University of Karachi, Karachi, Pakistan., Kenmogne SB; Faculty of Sciences, Chemistry Laboratory, University of Douala, Douala, Cameroon., Lobe Songue J; Faculty of Sciences, Chemistry Laboratory, University of Douala, Douala, Cameroon., Longue Ekon JP; Faculty of Sciences, Chemistry Laboratory, University of Douala, Douala, Cameroon., Lateef M; Multidisciplinary Research Lab, Bahria University Medical and Dental College, Karachi, Pakistan., Ngeufa Happi E; Faculty of Sciences, Chemistry Laboratory, University of Douala, Douala, Cameroon., Langat MK; Jodrell Laboratory, Natural Capital and Plant Health Department, Royal Botanic Gardens, Kew, Richmond, Surrey, TW9 3DS, United Kingdom., Tabekoueng GB; Faculty of Sciences, Chemistry Laboratory, University of Douala, Douala, Cameroon., Toze FAA; Faculty of Sciences, Chemistry Laboratory, University of Douala, Douala, Cameroon., Stammler HG; Department of Chemistry Inorganic and Structural Chemistry, Bielefeld University, Bielefeld, Germany., Ndjakou Lenta B; Department of Chemistry, Higher Teacher Training College University of Yaoundé, Yaounde, Cameroon., Wansi JD; Faculty of Sciences, Chemistry Laboratory, University of Douala, Douala, Cameroon., Sewald N; Organic and Bioorganic Chemistry Department of Chemistry, Bielefeld University, Bielefeld, Germany., Ali MS; H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences (ICCBS) University of Karachi, Karachi, Pakistan., Kamdem Waffo AF; Faculty of Sciences, Chemistry Laboratory, University of Douala, Douala, Cameroon. |
| Abstrakt: |
The phytochemical investigation of the methanolic extracts of roots, stem bark, leaves and twigs of Manilkara obovata has led to the isolation of one new friedelane triterpene, lacefriedelic acid or 3 β ,23-dihydroxy D:A-friedooleanan-28-oic acid ( 1 ) and one new prenylated xanthone, lacexanthone or 4,7-dihydroxy-2,3,3,9,9-pentamethyl-2,2-dihydrofurano[2,3-a]pyrano[2,3-i]xanthen-13( 9H )-one ( 2 ) alongside twenty-four known compounds. Compounds 1 - 11 are reported here for the first time from the genus Manilkara . The structures of all compounds were determined by spectroscopic analyses and X-ray crystallography. The methanolic extracts of twigs and leaves showed anti-oxidant activity of 93.2 and 91.1%, respectively, at 100 µg/mL when measured by DPPH (2,2-diphenyl-1-picryl-hydrazyl-hydrate), while the twig extract displayed 86.3% at 100 µg/mL against the urease inhibition assay. Some isolated compounds ( 1 - 4 , 15 and 20 ) showed significant to moderate anti-oxidant activity and urease inhibition assay. It is estimated that significantly active anti-oxidants and urease inhibitors metabolized by the plant may find future application in food industry. |
