Mitochondrial genetics cooperate with nuclear genetics to selectively alter immune cell development/trafficking.

Autor: Beadnell TC; Department of Cancer Biology, Department of Microbiology, Immunology and Genetics, The University of Kansas Cancer Center, The University of Kansas Medical Center, United States of America., Fain C; Department of Cancer Biology, Department of Microbiology, Immunology and Genetics, The University of Kansas Cancer Center, The University of Kansas Medical Center, United States of America., Vivian CJ; Department of Cancer Biology, Department of Microbiology, Immunology and Genetics, The University of Kansas Cancer Center, The University of Kansas Medical Center, United States of America., King JCG; Department of Cancer Biology, Department of Microbiology, Immunology and Genetics, The University of Kansas Cancer Center, The University of Kansas Medical Center, United States of America., Hastings R; Department of Cancer Biology, Department of Microbiology, Immunology and Genetics, The University of Kansas Cancer Center, The University of Kansas Medical Center, United States of America., Markiewicz MA; Department of Cancer Biology, Department of Microbiology, Immunology and Genetics, The University of Kansas Cancer Center, The University of Kansas Medical Center, United States of America., Welch DR; Department of Cancer Biology, Department of Microbiology, Immunology and Genetics, The University of Kansas Cancer Center, The University of Kansas Medical Center, United States of America. Electronic address: dwelch@kumc.edu.
Jazyk: angličtina
Zdroj: Biochimica et biophysica acta. Molecular basis of disease [Biochim Biophys Acta Mol Basis Dis] 2020 May 01; Vol. 1866 (5), pp. 165648. Date of Electronic Publication: 2019 Dec 30.
DOI: 10.1016/j.bbadis.2019.165648
Abstrakt: The nuclear genome drives differences in immune cell populations and differentiation potentials, in part regulated by changes in metabolism. Despite this connection, the role of mitochondrial DNA (mtDNA) polymorphisms (SNP) in this process has not been examined. Using mitochondrial nuclear exchange (MNX) mice, we and others have shown that mtDNA strongly influences varying aspects of cell biology and disease. Based upon an established connection between mitochondria and immune cell polarization, we hypothesized that mtDNA SNP alter immune cell development, trafficking, and/or differentiation. Innate and adaptive immune cell populations were isolated and characterizated from the peritoneum and spleen. While most differences between mouse strains are regulated by nuclear DNA (nDNA), there are selective changes that are mediated by mtDNA differences (e.g., macrophage (CD11c) differentiation), These findings highlight how nuclear-mitochondrial crosstalk may alter pathology and physiology via regulation of specific components of the immune system.
(Copyright © 2019 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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