| Autor: |
Olanipekun BE; Academy of Scientific and Innovative Research (AcSIR) , CSIR-IICT Campus , Hyderabad , 500007 , India.; Department of Chemical, Geological and Physical Sciences , Kwara State University Malete , P.M.B. 1530, Malete , Kwara State , Nigeria., Ponnapalli MG, Shaik K, Nanubolu JB, Kommalapati VK; Applied Biology , CSIR-Indian Institute of Chemical Technology (IICT) , Hyderabad , 500007 , India., Tangutur AD; Applied Biology , CSIR-Indian Institute of Chemical Technology (IICT) , Hyderabad , 500007 , India. |
| Abstrakt: |
Three new isomeric corniculatolides ( 1 , 2 , and 3 ) with an unusual caffrane and isocorniculane framework, and five known metabolites were isolated from the chloroform extract of the stems of Xylocarpus granatum . The structures of the new metabolites were deduced as corniculatolide B ( 1 ), isocorniculatolide B ( 2 ), and corniculatolide C ( 3 ) by spectroscopic data analysis and a combination of chemical transformations and supported by single-crystal X-ray crystallographic data of 1 and 3 . The isolated compounds were evaluated for their in vitro cytotoxicity and α-glucosidase ( Saccharomyces cerevisiae ) inhibitory potential. Compound 3 possessed α-glucosidase inhibitory activity with an IC 50 value of 24.8 μM, whereas these rare macrolides showed no effect on the mammalian cancer cell lines MIAPaCa-2, DU145, MCF-7, and HTC-116. |
