Effects of traumatic life events, cognitive biases and variation in dopaminergic genes on psychosis proneness.

Autor: Kotowicz K; Department of Psychiatry, Wroclaw Medical University, Wroclaw, Poland., Frydecka D; Department of Psychiatry, Wroclaw Medical University, Wroclaw, Poland., Gawęda Ł; Experimental Psychopathology Lab, Institute of Psychology, Polish Academy of Sciences, Warsaw, Poland., Prochwicz K; Institute of Psychology, Jagiellonian University, Krakow, Poland., Kłosowska J; Institute of Psychology, Jagiellonian University, Krakow, Poland., Rymaszewska J; Department of Psychiatry, Wroclaw Medical University, Wroclaw, Poland., Samochowiec A; Institute of Psychology, Department of Clinical Psychology, University of Szczecin, Szczecin, Poland., Samochowiec J; Department of Psychiatry, Pomeranian Medical University, Szczecin, Poland., Szczygieł K; Department of Psychiatry, Pomeranian Medical University, Szczecin, Poland., Pawlak-Adamska E; Department of Experimental Therapy, Laboratory of Immunopathology, Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wroclaw, Poland., Szmida E; Department of Genetics, Wroclaw Medical University, Wroclaw, Poland., Cechnicki A; Department of Community Psychiatry, Jagiellonian University Medical College, Cracow, Poland., Misiak B; Department of Genetics, Wroclaw Medical University, Wroclaw, Poland.
Jazyk: angličtina
Zdroj: Early intervention in psychiatry [Early Interv Psychiatry] 2021 Apr; Vol. 15 (2), pp. 248-255. Date of Electronic Publication: 2019 Dec 30.
DOI: 10.1111/eip.12925
Abstrakt: Aims: Recent studies have provided evidence that interactions between variation in dopaminergic genes and stressful experiences might impact risk of psychosis. However, it remains unknown whether these interactions impact the development of subclinical symptoms, including psychotic-like experiences (PLEs). In this study, we aimed to test the effects of interactions between variation in dopaminergic genes and traumatic life events (TLEs) on a severity of PLEs.
Methods: We assessed TLEs, cognitive biases, PLEs as well as the catechol-O-methyltransferase (COMT) rs4680 and the dopamine D2 receptor (DRD2) rs6277 gene polymorphisms in 445 university students at three urban areas.
Results: There was a significant effect of the interaction between the COMT rs4680 and a history of any type of TLEs on a severity of PLEs. Among the COMT rs4680 Met allele carriers, a severity of PLEs was higher in individuals with a history of any type of TLEs. Further stratification of the sample revealed that this effect appears only in the group of participants with a high level of cognitive biases. The DRD2 rs6277 C allele was independently associated with a higher level of PLEs.
Conclusions: Our results indicate that decreased dopamine catabolism related to the COMT gene polymorphism might increase psychosis proneness in individuals with a history of TLEs and high levels of cognitive biases. Variation in the DRD2 gene might exert independent effects on psychosis proneness. These findings imply that there are various levels of complexity in the models of interactions between genetic and environmental factors explaining the mechanisms underlying psychosis proneness.
(© 2019 John Wiley & Sons Australia, Ltd.)
Databáze: MEDLINE
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