Impact of SNPs/Haplotypes of IL10 and IFNG on the Development of Diffuse Large B-Cell Lymphoma.

Autor: Marangon AV; Faculdade de Ciências Médicas, Universidade Estadual de Campinas (UNICAMP), Brazil., Colli CM; Department of Basic Health Sciences, State University of Maringá (UEM), Av. Colombo, 5790, Maringá, Paraná, Brazil., Cardozo DM; Faculdade de Ciências Médicas, Universidade Estadual de Campinas (UNICAMP), Brazil., Visentainer JEL; Department of Basic Health Sciences, State University of Maringá (UEM), Av. Colombo, 5790, Maringá, Paraná, Brazil.; Postgraduate Program on Bioscience and Physiopathology, UEM, Brazil., Sell AM; Postgraduate Program on Bioscience and Physiopathology, UEM, Brazil., Guimaraes F; Hospital da Mulher Prof. Dr. José Aristodemo Pinott, Universidade Estadual de Campinas (UNICAMP), Brazil., Marques SBD; Faculdade de Ciências Médicas, Universidade Estadual de Campinas (UNICAMP), Brazil., Lieber SR; Faculdade de Ciências Médicas, Universidade Estadual de Campinas (UNICAMP), Brazil., Aranha FJP; Faculdade de Ciências Médicas, Universidade Estadual de Campinas (UNICAMP), Brazil., Zulli R; Faculdade de Ciências Médicas, Universidade Estadual de Campinas (UNICAMP), Brazil., de Souza VH; Postgraduate Program on Bioscience and Physiopathology, UEM, Brazil., de Souza CA; Faculdade de Ciências Médicas, Universidade Estadual de Campinas (UNICAMP), Brazil.
Jazyk: angličtina
Zdroj: Journal of immunology research [J Immunol Res] 2019 Nov 26; Vol. 2019, pp. 2137538. Date of Electronic Publication: 2019 Nov 26 (Print Publication: 2019).
DOI: 10.1155/2019/2137538
Abstrakt: The purpose of this study was to assess the influence of single-nucleotide polymorphisms (SNPs) on cytokine genes in the development of diffuse large B-cell lymphoma (DLBCL). One hundred and twelve patients and 221 controls were investigated. Among them, 97 patients treated with R-CHOP were subdivided into two groups: (i) complete remission of the disease and (ii) patients who progressed to death, relapsed, or had disease progression. The SNPs investigated by PCR-SSP were TNF -308G>A (rs1800629), IFNG +874A>T (rs2430561), IL6 -174G>C (rs1800795), IL10 -1082A>G (rs1800896), IL10 -819C>T (rs1800871), IL10 -592C>A (rs1800872), and TGFB1 codon10T>C (rs1982073) and codon25G>C (rs1800471). In general, the genotypes that have been associated in the literature with lower production or intermediate production of IL-10 and higher production of IFN- γ were associated with the protection of the development of the disease, possibly favoring the Th1 immune response and diminishing the capacity of cell proliferation. However, patients receiving R-CHOP treatment presented unfavorable prognoses in the presence of genotypes related to the intermediate production of IL-10 and high production of TGF- β 1, indicating that cytokines may be related to the response to treatment and action mechanisms of Rituximab.
Competing Interests: The authors declare that there is no conflict of interest regarding the publication of this article.
(Copyright © 2019 Amanda Vansan Marangon et al.)
Databáze: MEDLINE
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