| Autor: |
Griffen AL; Division of Pediatric Dentistry, The Ohio State University College of Dentistry, Columbus, OH, USA. griffen.1@osu.edu., Thompson ZA; Division of Biosciences, The Ohio State University College of Dentistry, Columbus, OH, USA., Beall CJ; Division of Biosciences, The Ohio State University College of Dentistry, Columbus, OH, USA., Lilly EA; Center of Excellence in Oral and Craniofacial Biology, Louisiana State University Health Sciences Center School of Dentistry, New Orleans, LA, USA., Granada C; Division of Infectious Diseases, Department of Medicine, Medical College of Georgia/Augusta University, Augusta, GA, USA., Treas KD; Center of Excellence in Oral and Craniofacial Biology, Louisiana State University Health Sciences Center School of Dentistry, New Orleans, LA, USA., DuBois KR 3rd; Center of Excellence in Oral and Craniofacial Biology, Louisiana State University Health Sciences Center School of Dentistry, New Orleans, LA, USA., Hashmi SB; Division of Biosciences, The Ohio State University College of Dentistry, Columbus, OH, USA., Mukherjee C; Division of Biosciences, The Ohio State University College of Dentistry, Columbus, OH, USA., Gilliland AE; Center of Excellence in Oral and Craniofacial Biology, Louisiana State University Health Sciences Center School of Dentistry, New Orleans, LA, USA., Vazquez JA; Division of Infectious Diseases, Department of Medicine, Medical College of Georgia/Augusta University, Augusta, GA, USA., Hagensee ME; Section of Infectious Disease, Department of Medicine, Louisiana State University Health Sciences Center, New Orleans, LA, USA., Leys EJ; Division of Biosciences, The Ohio State University College of Dentistry, Columbus, OH, USA., Fidel PL Jr; Center of Excellence in Oral and Craniofacial Biology, Louisiana State University Health Sciences Center School of Dentistry, New Orleans, LA, USA. |
| Abstrakt: |
Persons infected with HIV are particularly vulnerable to a variety of oral microbial diseases. Although various study designs and detection approaches have been used to compare the oral microbiota of HIV-negative and HIV-positive persons, both with and without highly active antiretroviral therapy (HAART), methods have varied, and results have not been consistent or conclusive. The purpose of the present study was to compare the oral bacterial community composition in HIV-positive persons under HAART to an HIV-negative group using 16S rRNA gene sequence analysis. Extensive clinical data was collected, and efforts were made to balance the groups on clinical variables to minimize confounding. Multivariate analysis was used to assess the independent contribution of HIV status. Eighty-nine HIV-negative participants and 252 HIV-positive participants under HAART were sampled. The independent effect of HIV under HAART on the oral microbiome was statistically significant, but smaller than the effect of gingivitis, periodontal disease, smoking, caries, and other clinical variables. In conclusion, a multivariate comparison of a large sample of persons with HIV under HAART to an HIV-negative control group showed a complex set of clinical features that influenced oral bacterial community composition, including the presence of HIV under HAART. |
