Effect of nebivolol on altered skeletal and cardiac muscles induced by dyslipidemia in rats: impact on oxidative and inflammatory machineries.

Autor: Soliman GF; Department of Medical Pharmacology, Cairo University, Cairo, Egypt., Abdel-Maksoud OM; Department of Medical Physiology, Cairo University, Cairo, Egypt., Khalifa MM; Department of Medical Physiology, Cairo University, Cairo, Egypt., Rashed LA; Department of Medical Biochemistry, Cairo University, Cairo, Egypt., Ibrahim W; Department of Medical Biochemistry, Cairo University, Cairo, Egypt., Morsi H; Department of Medical Biochemistry, Cairo University, Cairo, Egypt., Abdallah H; Department of Medical Histology, Faculty of Medicine, Cairo University, Cairo, Egypt., Bastawy N; Department of Medical Physiology, Cairo University, Cairo, Egypt.
Jazyk: angličtina
Zdroj: Archives of physiology and biochemistry [Arch Physiol Biochem] 2022 Apr; Vol. 128 (2), pp. 463-473. Date of Electronic Publication: 2019 Dec 26.
DOI: 10.1080/13813455.2019.1693599
Abstrakt: Aim: High cholesterol diet is greatly linked to deleterious health consequences. In this work we tried to explore direct effects of high cholesterol diet on striated (skeletal and cardiac) muscle tissues and the mechanisms by which nebivolol could improve such harmful effects.
Methods: The study included 24 healthy adult male albino rats weighing 200-220 grams that were assigned into four groups: control group, control drug group, high cholesterol diet fed groups; one untreated the other was treated with nebivolol.
Results: In the cholesterol fed group, we found decreased blood HDL and NO with elevated total cholesterol, triglycerides, myoglobin, CK, LDH, ALP, in addition to elevated muscle tissue levels of HIF-1, NF-kB, MDA, and decreased expression of both eNOS, reduced GSH. Wire hanging test time was shorter in the high cholesterol group than control group rats, which was confirmed histologically by increased striated muscle fibre thickness and cytochrome area %. Nebivolol treatment ameliorated the effects of high cholesterol diet.
Conclusion: High cholesterol diet caused myopathic changes in rat striated muscle tissues mostly due to oxidative stress associated with enhanced NF-kB and HIF-1 expression. Nebivolol appears beneficial in the management of hypercholesterolaemia-induced striated muscle injury.
Databáze: MEDLINE
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