Morphometry and comparative histology of sinus and atrioventricular nodes in humans and pigs and their relevance in the prevention of nodal arrhythmias.

Autor: Gómez-Torres FA; Department of Pathology, Faculty of Medicine, Universitat de Valencia, Av. de Blasco Ibáñez, 15, 46010 Valencia, Spain; Department of Basic Sciences, Medicine School, Universidad Industrial de Santander, Cra 32 # 29-31, 68002 Bucaramanga, Colombia. Electronic address: falegom@uis.edu.co., Sebastian R; Computational Multiscale Simulation Lab, Universitat de Valencia, Valencia 46100, Spain. Electronic address: rafael.sebastian@uv.es., Ruíz-Sauri A; Department of Pathology, Faculty of Medicine, Universitat de Valencia, Av. de Blasco Ibáñez, 15, 46010 Valencia, Spain; INCLIVA Biomedical Research Institute, Av. de Blasco Ibáñez, 17, 46010 Valencia, Spain. Electronic address: Amparo.Ruiz-Sauri@uv.es.
Jazyk: angličtina
Zdroj: Research in veterinary science [Res Vet Sci] 2020 Feb; Vol. 128, pp. 275-285. Date of Electronic Publication: 2019 Dec 05.
DOI: 10.1016/j.rvsc.2019.12.008
Abstrakt: The cardiac conduction system is a network structure that allows the initiation and fast propagation of electrical impulses that trigger the electrical depolarization of the myocardial tissue. The purpose of this work is to study the histological and morphometric characteristics of the different components of the sinus and atrioventricular nodes in humans and pigs and their relationship with supraventricular arrhythmias. In this study, we describe the morphometry of the sinus and atrioventricular nodes of 10 adult humans and 10 pig hearts. A computerized morphometric study has been carried out, where we determined the number of cells that compose the nodes as well as different parameters related to their shape and size. The sinus node in human and pig is a compact structure, whose shape is oblong. Their cells (nodal and transitional cells) are pale and located in the center and the periphery, respectively. The atrioventricular node has also a shape oblong. P cells are pale in both species, but in humans, they are smaller than cardiomyocytes. The T cells are small and pale in both species, identified by hematoxylin-eosin and desmin stains. We have observed through a morphometric profile that the structure of sinus and atrioventricular nodes of pigs and humans show few differences. Pigs can be used as models for hemodynamic applications and experimental studies that include atrial electrical conduction and, in this way, prevent the presentation of arrhythmias that can generate sudden deaths in humans and pigs.
(Copyright © 2019. Published by Elsevier Ltd.)
Databáze: MEDLINE
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