Acetylcholine Regulates Olfactory Perceptual Learning through Effects on Adult Neurogenesis.

Autor:	Schilit Nitenson A; Department of Neuroscience, Brown University, Providence, RI 02912, USA., Manzano Nieves G; Department of Neuroscience, Brown University, Providence, RI 02912, USA., Poeta DL; Department of Cognitive, Linguistic and Psychological Sciences, Brown University, 190 Thayer St., Box 1821, Providence, RI 02912, USA., Bahar R; Department of Neuroscience, Brown University, Providence, RI 02912, USA., Rachofsky C; Department of Neuroscience, Brown University, Providence, RI 02912, USA., Mandairon N; INSERM, U1028, CNRS, UMR5292, Lyon Neuroscience Research Center, Lyon 69000, France., Bath KG; Department of Cognitive, Linguistic and Psychological Sciences, Brown University, 190 Thayer St., Box 1821, Providence, RI 02912, USA. Electronic address: kevin_bath@brown.edu.
Jazyk:	angličtina
Zdroj:	IScience [iScience] 2019 Dec 20; Vol. 22, pp. 544-556. Date of Electronic Publication: 2019 Nov 14.
DOI:	10.1016/j.isci.2019.11.016
Abstrakt:	Learning to perceptually discriminate between chemical signals in the environment (olfactory perceptual learning [OPL]) is critical for survival. Multiple mechanisms have been implicated in OPL, including modulation of neurogenesis and manipulation of cholinergic activity. However, whether these represent distinct processes regulating OPL or if cholinergic effects on OPL depend upon neurogenesis has remained an unresolved question. Using a combination of pharmacological and optogenetic approaches, cholinergic activity was shown to be both necessary and sufficient to drive OPL, and this process was dependent on the presence of newly born cells in the olfactory bulb (OB). This study is the first to directly demonstrate that cholinergic effects on OPL require adult OB neurogenesis. (Copyright © 2019 The Author(s). Published by Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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