A 15 year institutional experience of well-differentiated follicular cell-derived thyroid carcinomas; impact of the new 2017 TNM and WHO Classifications of Tumors of Endocrine Organs on the epidemiological trends and pathological characteristics.

Autor: Borda A; Department of Histology, George Emil Palade University of Medicine, Pharmacy, Sciences, and Technology of Targu-Mureş, 38 Gh. Marinescu Street, 540139, Targu-Mureş, Romania.; Department of Pathology, Targu-Mureş Emergency County Hospital, 50 Gh. Marinescu Street, 540136, Targu-Mureş, Romania., Zahan AE; Department of Histology, George Emil Palade University of Medicine, Pharmacy, Sciences, and Technology of Targu-Mureş, 38 Gh. Marinescu Street, 540139, Targu-Mureş, Romania. ancutazahan@gmail.com., Piciu D; Department of Nuclear Medicine, 'Ion Chiricuţă' Institute of Oncology, 34-36 Republicii Street, Cluj-Napoca, 400015, Romania., Barbuș E; Department of Nuclear Medicine, 'Ion Chiricuţă' Institute of Oncology, 34-36 Republicii Street, Cluj-Napoca, 400015, Romania., Berger N; Department of Pathology Centre Hospitalier Lyon Sud, Hospices Civils de Lyon, 69495, Pierre Bénite, France., Nechifor-Boilă A; Department of Histology, George Emil Palade University of Medicine, Pharmacy, Sciences, and Technology of Targu-Mureş, 38 Gh. Marinescu Street, 540139, Targu-Mureş, Romania.; Department of Pathology, Targu-Mureş County Hospital, 28 December 1/1918 Boulevard, 540061, Targu-Mureş, Romania.
Jazyk: angličtina
Zdroj: Endocrine [Endocrine] 2020 Mar; Vol. 67 (3), pp. 630-642. Date of Electronic Publication: 2019 Dec 14.
DOI: 10.1007/s12020-019-02158-7
Abstrakt: Purpose: Our study aimed to describe the evolution of the rate of pathological subtypes of well-differentiated follicular-cell derived thyroid carcinomas (DTCs) in the Department of Pathology, Emergency County Hospital Targu-Mures, Romania over a 15 year period and to assess the impact the new 2017 WHO and TNM classifications of thyroid tumors had on our cases.
Methods: The pathological data were retrieved from the original pathological reports. After applying the exclusion criteria the remaining cases were reviewed on a double-headed microscope and reclassified according to the 2017 WHO and TNM staging system. The follow-up data were collected from the Institute of Oncology Cluj-Napoca, Romania.
Results: Our study included 396 cases of DTCs (375 papillary, 11 follicular, and 10 Hürthle cell carcinomas). PTCs revealed a significant increasing trend over the study period, whereas follicular and Hurthle cell carcinomas remain rare; 125/131 of noninvasive encapsulated follicular variant PTC (EFVPTC) were reclassified as noninvasive follicular thyroid neoplasms with papillary-like nuclear features (NIFTPs), resulting in a 33.3% reduction in the number of PTCs. According to 2017 TNM stage-grouping 31% of 271 patients with DTC were downstaged. Follow-up data were available for most of the patients (65.7%, mean period 58.1 months). All patients with noninvasive EFVPTC were disease free at the last clinical assessment.
Conclusions: The increasing rate of PTC was maintained even after exclusion of NIFTP. By applying 2017 TNM criteria, a significant number of DTC cases were downstaged into a more favorable group. Follow-up data highlight the indolent behavior of noninvasive EFVPTCs reclassified as NIFTPs.
Databáze: MEDLINE
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