Dance Training Improves Cytokine Secretion and Viability of Neutrophils in Diabetic Patients.

Autor: Borges L; Institute of Physical Activity and Sports Sciences, Cruzeiro do Sul University, São Paulo 01506-000, Brazil., Passos MEP; Institute of Physical Activity and Sports Sciences, Cruzeiro do Sul University, São Paulo 01506-000, Brazil., Silva MBB; Institute of Physical Activity and Sports Sciences, Cruzeiro do Sul University, São Paulo 01506-000, Brazil., Santos VC; São Paulo University (USP), São Paulo 05508-900, Brazil., Momesso CM; Institute of Physical Activity and Sports Sciences, Cruzeiro do Sul University, São Paulo 01506-000, Brazil., Pithon-Curi TC; Institute of Physical Activity and Sports Sciences, Cruzeiro do Sul University, São Paulo 01506-000, Brazil., Gorjão R; Institute of Physical Activity and Sports Sciences, Cruzeiro do Sul University, São Paulo 01506-000, Brazil., Gray SR; Institute of Cardiovascular & Medical Sciences, University of Glasgow, Glasgow G12 8TA, UK., Lima KCA; Institute of Physical Activity and Sports Sciences, Cruzeiro do Sul University, São Paulo 01506-000, Brazil., de Freitas PB; Institute of Physical Activity and Sports Sciences, Cruzeiro do Sul University, São Paulo 01506-000, Brazil.; Department of Neurology, Milton S. Hershey Medical Center, The Pennsylvania State University, Hershey, PA 16801, USA.; Department of Kinesiology, The Pennsylvania State University, University Park, PA 16802, USA., Hatanaka E; Institute of Physical Activity and Sports Sciences, Cruzeiro do Sul University, São Paulo 01506-000, Brazil.
Jazyk: angličtina
Zdroj: Mediators of inflammation [Mediators Inflamm] 2019 Nov 20; Vol. 2019, pp. 2924818. Date of Electronic Publication: 2019 Nov 20 (Print Publication: 2019).
DOI: 10.1155/2019/2924818
Abstrakt: Background: Evidence suggests that exercise improves neutrophil function. The decreased functional longevity of neutrophils and their increased clearance from infectious sites contribute to the increased susceptibility to infection and severity of infection observed in patients with diabetes.
Objective: Herein, we investigated the effects of a dance program on neutrophil number, function, and death in type 2 diabetes mellitus (T2DM) patients and healthy volunteers.
Methods: Ten patients with T2DM and twelve healthy individuals participated in a moderate-intensity dance training program for 4 months. The plasma levels of leptin, free fatty acids (FFAs), tumour necrosis factor- α (TNF- α ), C-reactive protein (CRP), interleukin-1 β (IL-1 β ), and interleukin-1 receptor antagonist (IL-1ra); neutrophil counts; extent of DNA fragmentation; cell membrane integrity; and production of TNF- α , interleukin-8 (IL-8), interleukin-6 (IL-6), and IL-1 β in neutrophils were measured before and after training.
Results: Training reduced plasma levels of TNF- α (1.9-fold in controls and 2.2-fold in patients with T2DM) and CRP (1.4-fold in controls and 3.4-fold in patients with T2DM). IL-1ra levels were higher in the control group (2.2-fold) after training. After training, neutrophil DNA fragmentation was decreased in patients with T2DM (90%), while the number of neutrophils increased (70% in controls and 1.1-fold in patients with T2DM).
Conclusion: Dance training is a nonpharmacological strategy to reduce inflammation and improve neutrophil clearance in patients with T2DM.
Competing Interests: The authors declare that they have no conflicts of interest.
(Copyright © 2019 Leandro Borges et al.)
Databáze: MEDLINE
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