The Role of Environmental Factors in the Etiology of Nonsyndromic Orofacial Clefts.

Autor:	Eshete M; Surgical Department, School of Medicine, College of Health Sciences, Addis Ababa University.; Plastic and Reconstructive Surgery Unit, Yekatit 12 Hospital Medical College.; Department of Preventive Medicine, School of Public Health, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia., Butali A; Department of Oral Pathology, Radiology, and Medicine, College of Dentistry, University of Iowa, Iowa City, IA., Abate F; Plastic and Reconstructive Surgery Unit, Yekatit 12 Hospital Medical College., Hailu T; Plastic and Reconstructive Surgery Unit, Yekatit 12 Hospital Medical College., Hailu A; Surgical Department, School of Medicine, College of Health Sciences, Addis Ababa University.; Plastic and Reconstructive Surgery Unit, Yekatit 12 Hospital Medical College., Degu S; Dental Department, School of Medicine, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia., Demissie Y; Surgical Department, School of Medicine, College of Health Sciences, Addis Ababa University.; Plastic and Reconstructive Surgery Unit, Yekatit 12 Hospital Medical College., Gravem PE; Plastic and Reconstructive Surgery Department, Haukeland University Hospital, Bergen, Norway., Derbew M; Surgical Department, School of Medicine, College of Health Sciences, Addis Ababa University., Mossey P; Department of Orthodontics, University of Dundee, Scotland, UK., Bush T; Department of Oral Pathology, Radiology, and Medicine, College of Dentistry, University of Iowa, Iowa City, IA., Deressa W; Department of Preventive Medicine, School of Public Health, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia.
Jazyk:	angličtina
Zdroj:	The Journal of craniofacial surgery [J Craniofac Surg] 2020 Jan/Feb; Vol. 31 (1), pp. 113-116.
DOI:	10.1097/SCS.0000000000005924
Abstrakt:	Background: Nonsyndromic orofacial clefts (NSOFCs) represent the most common congenital anomalies in the head and neck region. Multiple factors contribute to the occurrence of this anomaly. The etiology of NSOFCs in the Ethiopian population has not been investigated prior to this study. Aims of the Study: To assess the role of maternal environmental factors in the occurrence of NSOFCs in the Ethiopian Population. Methods: The authors used unmatched case control study design and evaluated the role of environmental factors to the occurrence of NSOFCs in the Ethiopian population. The participants were recruited from the same institution (Yekatit 12 Hospital Medical College). The authors studied 760 mothers (359 mothers of children born with NSOFCs and 401 mothers of children born without any congenital anomalies). Univariate and multivariate logistic regression analyses were used to calculate relative risk by odds ratio and 95% confidence interval. Results: Mothers who gave history of bronchial asthma and mothers who were admitted for threatened abortion had a higher risk of delivering a child with NSOFCS P value=0.013; AOR=0.194, 95% CI [0.053-0.712], P value <0.001; AOR= 0.179, 95% CI [0.091-0.352] respectively. Higher number of children with NSOFCs were born to mothers who were exposed to diagnostic X-ray investigation during early pregnancy than those who were not exposed P value 0.048; AOR=0.375, 95% CI [0.142-0.990]. Conclusion: Maternal exposure to diagnostic x-ray, maternal chronic illness like bronchial asthma and threatened abortion were found to be associated with the occurrence of NSOFCS in the studied population.
Databáze:	MEDLINE
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