Risk assessment for the implementation of controlled human Schistosoma mansoni infection trials in Uganda.

Autor:	Koopman JP; Department of Parasitology, Leiden University Medical Center, Leiden, The Netherlands., Egesa M; Uganda Virus Research Institute, Entebbe, Uganda., Wajja A; Medical Research Council/Uganda Virus Research Institute and London School of Hygiene & Tropical Medicine Uganda Research Unit, Entebbe, Uganda., Adriko M; Vector Control Division, Ministry of Health of Uganda, Kampala, Uganda., Nassuuna J; Medical Research Council/Uganda Virus Research Institute and London School of Hygiene & Tropical Medicine Uganda Research Unit, Entebbe, Uganda., Nkurunungi G; Medical Research Council/Uganda Virus Research Institute and London School of Hygiene & Tropical Medicine Uganda Research Unit, Entebbe, Uganda., Driciru E; Medical Research Council/Uganda Virus Research Institute and London School of Hygiene & Tropical Medicine Uganda Research Unit, Entebbe, Uganda., van Willigen G; Department of Health, Safety and the Environment, Leiden University Medical Center, Leiden, The Netherlands., Cose S; Medical Research Council/Uganda Virus Research Institute and London School of Hygiene & Tropical Medicine Uganda Research Unit, Entebbe, Uganda.; Clinical Research Department, London School of Hygiene & Tropical Medicine, London, UK., Yazdanbakhsh M; Department of Parasitology, Leiden University Medical Center, Leiden, The Netherlands., Kaleebu P; Medical Research Council/Uganda Virus Research Institute and London School of Hygiene & Tropical Medicine Uganda Research Unit, Entebbe, Uganda., Kabatereine N; Vector Control Division, Ministry of Health of Uganda, Kampala, Uganda., Tukahebwa E; Vector Control Division, Ministry of Health of Uganda, Kampala, Uganda., Roestenberg M; Department of Parasitology, Leiden University Medical Center, Leiden, The Netherlands., Elliott AM; Medical Research Council/Uganda Virus Research Institute and London School of Hygiene & Tropical Medicine Uganda Research Unit, Entebbe, Uganda.; Clinical Research Department, London School of Hygiene & Tropical Medicine, London, UK.
Jazyk:	angličtina
Zdroj:	AAS open research [AAS Open Res] 2019 Aug 13; Vol. 2, pp. 17. Date of Electronic Publication: 2019 Aug 13 (Print Publication: 2019).
DOI:	10.12688/aasopenres.12972.2
Abstrakt:	Schistosomiasis is a parasitic infection highly prevalent in sub-Saharan Africa, and a significant cause of morbidity; it is a priority for vaccine development. A controlled human infection model for Schistosoma mansoni (CHI-S) with potential to accelerate vaccine development has been developed among naïve volunteers in the Netherlands. Because responses both to infections and candidate vaccines are likely to differ between endemic and non-endemic settings, we propose to establish a CHI-S in Uganda where Schistosoma mansoni is endemic. As part of a "road-map" to this goal, we have undertaken a risk assessment. We identified risks related to importing of laboratory vector snails and schistosome strains from the Netherlands to Uganda; exposure to natural infection in endemic settings concurrently with CHI-S studies, and unfamiliarity of the community with the nature, risks and rationale for CHI. Mitigating strategies are proposed. With careful implementation of the latter, we believe that CHI-S can be implemented safely in Uganda. Our reflections are presented here to promote feedback and discussion. Competing Interests: Competing interests: The authors have declared no personal financial competing interests. However, we are working collaboratively to develop the CHI-S for implementation in Uganda, and therefore have research goals with potential to influence our approach to this risk assessment. This is, in part, our motivation for publishing it on an open peer review platform. (Copyright: © 2019 Koopman JP et al.)
Databáze:	MEDLINE
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