The association between hippocampal subfield volumes in mild cognitive impairment and conversion to Alzheimer's disease.

Autor: Izzo J; Department of Psychology, University of Turin, Italy. Electronic address: jessicaizzo92@gmail.com., Andreassen OA; NORMENT, Division of Mental Health and Addiction, Oslo University Hospital & Institute of Clinical Medicine, University of Oslo, Norway., Westlye LT; Department of Psychology, University of Oslo, Norway., van der Meer D; NORMENT, Division of Mental Health and Addiction, Oslo University Hospital & Institute of Clinical Medicine, University of Oslo, Norway; School of Mental Health and Neuroscience, Faculty of Health, Medicine and Life Sciences, Maastricht University, The Netherlands.
Jazyk: angličtina
Zdroj: Brain research [Brain Res] 2020 Feb 01; Vol. 1728, pp. 146591. Date of Electronic Publication: 2019 Dec 07.
DOI: 10.1016/j.brainres.2019.146591
Abstrakt: The hippocampal complex, strongly implicated in Alzheimer's disease (AD), is a region with functionally and structurally distinct subfields. Hippocampal subfield volumes may represent a more sensitive indicators of AD development than total hippocampal volume. We aimed to identify which subfield is the most predictive measure for an AD diagnosis and which is the most specific indicator of the conversion from mild cognitive impairment (MCI) to AD. We analyzed longitudinal structural neuroimaging data of 1350 individuals, 350 healthy controls (HC), 650 MCI and 350 AD, using FreeSurfer v6.0. The linear regression models corrected for total hippocampal volume revealed that subicular fields are the most predictive measures of AD diagnosis. Hippocampal fissure volume was significantly associated with conversion from MCI to AD. Our findings suggest that subicular hippocampal fields are most predictive of AD diagnosis, which has clinical implications for early detection. Specifically, subicular and hippocampal fissure volume measures may be used to select MCI participants who are most likely to convert in AD in clinical trials.
(Copyright © 2019 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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