Libidibia ferrea (jucá), a Traditional Anti-Inflammatory: A Study of Acute Toxicity in Adult and Embryos Zebrafish ( Danio rerio ).

Autor: Ferreira DQ; Department of Biological and Health Sciences, Federal University of Amapá, Rodovia Juscelino Kubitisheck, km 02, CEP 68902 280, Macapá, Amapá, Brazil.; Laboratory of Phytopharmaceutical Nanobiotechnology, Department of Biological and Health Sciences, Federal University of Amapá, Rodovia Juscelino Kubitisheck, km 02, CEP 68902 280, Macapá, Amapá, Brazil., Ferraz TO; Department of Biological and Health Sciences, Federal University of Amapá, Rodovia Juscelino Kubitisheck, km 02, CEP 68902 280, Macapá, Amapá, Brazil.; Laboratory of Phytopharmaceutical Nanobiotechnology, Department of Biological and Health Sciences, Federal University of Amapá, Rodovia Juscelino Kubitisheck, km 02, CEP 68902 280, Macapá, Amapá, Brazil., Araújo RS; Department of Biological and Health Sciences, Federal University of Amapá, Rodovia Juscelino Kubitisheck, km 02, CEP 68902 280, Macapá, Amapá, Brazil.; Laboratory of Phytopharmaceutical Nanobiotechnology, Department of Biological and Health Sciences, Federal University of Amapá, Rodovia Juscelino Kubitisheck, km 02, CEP 68902 280, Macapá, Amapá, Brazil., Cruz RAS; Department of Biological and Health Sciences, Federal University of Amapá, Rodovia Juscelino Kubitisheck, km 02, CEP 68902 280, Macapá, Amapá, Brazil.; Laboratory of Phytopharmaceutical Nanobiotechnology, Department of Biological and Health Sciences, Federal University of Amapá, Rodovia Juscelino Kubitisheck, km 02, CEP 68902 280, Macapá, Amapá, Brazil., Fernandes CP; Department of Biological and Health Sciences, Federal University of Amapá, Rodovia Juscelino Kubitisheck, km 02, CEP 68902 280, Macapá, Amapá, Brazil.; Laboratory of Phytopharmaceutical Nanobiotechnology, Department of Biological and Health Sciences, Federal University of Amapá, Rodovia Juscelino Kubitisheck, km 02, CEP 68902 280, Macapá, Amapá, Brazil., Souza GC; Pharmaceutical Research Laboratory, Department of Biological and Health Sciences, Federal University of Amapá, Rodovia Juscelino Kubitisheck, km 02, CEP 68902 280, Macapá, Amapá, Brazil., Ortiz BLS; Pharmaceutical Research Laboratory, Department of Biological and Health Sciences, Federal University of Amapá, Rodovia Juscelino Kubitisheck, km 02, CEP 68902 280, Macapá, Amapá, Brazil., Sarquis RSFR; Pharmaceutical Research Laboratory, Department of Biological and Health Sciences, Federal University of Amapá, Rodovia Juscelino Kubitisheck, km 02, CEP 68902 280, Macapá, Amapá, Brazil., Miranda JCMM; Molecular Biology Laboratory, Department of Biological and Health Sciences, Federal University of Amapá, Rodovia Juscelino Kubitisheck, km 02, CEP 68902 280, Macapá, Amapá, Brazil., Garrett R; Metabolomics Laboratory, Institute of Chemistry, Federal University of Rio de Janeiro, RJ 21941-902, Brazil., Carvalho JCT; Department of Biological and Health Sciences, Federal University of Amapá, Rodovia Juscelino Kubitisheck, km 02, CEP 68902 280, Macapá, Amapá, Brazil.; Pharmaceutical Research Laboratory, Department of Biological and Health Sciences, Federal University of Amapá, Rodovia Juscelino Kubitisheck, km 02, CEP 68902 280, Macapá, Amapá, Brazil., Oliveira AEMFM; Department of Biological and Health Sciences, Federal University of Amapá, Rodovia Juscelino Kubitisheck, km 02, CEP 68902 280, Macapá, Amapá, Brazil.; Laboratory of Phytopharmaceutical Nanobiotechnology, Department of Biological and Health Sciences, Federal University of Amapá, Rodovia Juscelino Kubitisheck, km 02, CEP 68902 280, Macapá, Amapá, Brazil.
Jazyk: angličtina
Zdroj: Pharmaceuticals (Basel, Switzerland) [Pharmaceuticals (Basel)] 2019 Nov 30; Vol. 12 (4). Date of Electronic Publication: 2019 Nov 30.
DOI: 10.3390/ph12040175
Abstrakt: The plant species Libidibia ferrea (Mart. ex Tul.) LP Queiroz var. ferrea basionym of Caesalpinia ferrea (Mart. ex Tul.) is used in various regions of Brazil in folk medicine in the treatment of several health problems, especially in acute and chronic inflammatory processes. Most of the preparations employed are alcoholic. Therefore, this study aimed to evaluate the acute toxicity of the hydroethanolic extract of fruits of Libidibia ferrea (EHEFLf) in zebrafish, emphasizing the possible changes in the organic-cellular level of the gills, liver, kidneys, and intestine and on embryos. The result obtained by LC-M/MS from EHEFLf indicated a high concentration of possible polyhydroxylated substances. EHEFLf, at a dose of 2 g/kg orally, produced non-significant alterations of the analyzed organs. However, for embryos, the treatment with different concentrations demonstrated heart toxicity that was concentration-dependent. There is no evidence of a correlation of the observed effects with the phytochemical composition, and considering the species of animal used, it can be suggested that the oral use of L. ferrea hydroethanolic extract has an acceptable degree of safety for use as an oral medicinal product. and embryo results have shown significant affinity to the heart; however, it is perceived to be related to the concentrations used.
Competing Interests: The authors declare no conflict of interest.
Databáze: MEDLINE
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