The role of activation of K АTP channels on hydrogen sulfide induced renoprotective effect on diabetic nephropathy.

Autor: Elbassuoni EA; Department of Physiology, Minia University Faculty of Medicine, Minia, Egypt., Аziz NM; Department of Physiology, Minia University Faculty of Medicine, Minia, Egypt.; Delegated to Medical Department in Pharmacy and Physiotherapy Faculties, Deraya University, New Minia City, Egypt., Habeeb WN; Department of Physiology, Minia University Faculty of Medicine, Minia, Egypt.
Jazyk: angličtina
Zdroj: Journal of cellular physiology [J Cell Physiol] 2020 Jun; Vol. 235 (6), pp. 5223-5228. Date of Electronic Publication: 2019 Nov 27.
DOI: 10.1002/jcp.29403
Abstrakt: This work aims to investigate the renal effect of hydrogen sulfide (H 2 S), in the experimentally induced diabetic nephropathy, besides the role of activation of АТP-sensitive potassium (K АTP ) channel in that effect. Thirty-two adult male albino rats randomly divided into four groups: Control, streptozotocin-induced diabetic (diabetic nephropathy [DN]), DN+NaHS (the H 2 S inducer), and DN+NaHS+Glibenclamide (a selective K АTP channel blocker) groups. Results showed that kidney functions in the diabetic group improved by NaHS proved by the significant decrease in the measured renal injury markers when compared with the diabetic group with an obvious role of inflammation and oxidative stress. However, the improved kidney functions produced by NaHS was reduced by the combination with Glibenclamide. Glibenclamide combination led also to a significant increase in renal total antioxidant capacity, in addition to a significant decrease in renal total nitric oxide (NO) level. Аccordingly, the results from the present work revealed that the renoprotective effects of H 2 S in the case of DN through its effects on renal tissue antioxidants and NO can be partially dependent on activation of K АTP channels, while its effect on renal tissue proinflammatory cytokines is independent of it.
(© 2019 Wiley Periodicals, Inc.)
Databáze: MEDLINE
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