Aggregatibacter Actinomycetemcomitans : Clinical Significance of a Pathobiont Subjected to Ample Changes in Classification and Nomenclature.
| Autor: | Nørskov-Lauritsen N; Department of Clinical Microbiology, Aarhus University Hospital, DK-8200 Aarhus N, Denmark., Claesson R; Department of Odontology, Division of Oral Microbiology, Umeå University, S-901 87 Umeå, Sweden., Birkeholm Jensen A; Department of Dentistry and Oral Health, Aarhus University, DK-8000 Aarhus C, Denmark., Åberg CH; Department of Odontology, Division of Molecular Periodontology, Umeå University, S-901 87 Umeå, Sweden., Haubek D; Department of Dentistry and Oral Health, Aarhus University, DK-8000 Aarhus C, Denmark. |
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| Jazyk: | angličtina |
| Zdroj: | Pathogens (Basel, Switzerland) [Pathogens] 2019 Nov 18; Vol. 8 (4). Date of Electronic Publication: 2019 Nov 18. |
| DOI: | 10.3390/pathogens8040243 |
| Abstrakt: | Aggregatibacter actinomycetemcomitans is a Gram-negative bacterium that is part of the oral microbiota. The aggregative nature of this pathogen or pathobiont is crucial to its involvement in human disease. It has been cultured from non-oral infections for more than a century, while its portrayal as an aetiological agent in periodontitis has emerged more recently. A. actinomycetemcomitans is one species among a plethora of microorganisms that constitute the oral microbiota. Although A. actinomycetemcomitans encodes several putative toxins, the complex interplay with other partners of the oral microbiota and the suppression of host response may be central for inflammation and infection in the oral cavity. The aim of this review is to provide a comprehensive update on the clinical significance, classification, and characterisation of A. actinomycetemcomitans , which has exclusive or predominant host specificity for humans. Competing Interests: The authors declare no conflict of interest. |
| Databáze: | MEDLINE |
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