A combined intrapleural administration of dornase alfa and tissue plasminogen activator is safe in children with empyema - A pilot study.

Autor:	Slaats MA; Department of Paediatric Medicine, Antwerp University Hospital, Belgium., De Dooy J; Department of Paediatric Intensive Care, Antwerp University Hospital Belgium., Van Hoorenbeeck K; Department of Paediatric Medicine, Antwerp University Hospital, Belgium., Van Schil PEY; Department of Thoracic and Vascular Surgery, Antwerp University Hospital, Belgium., Verhulst SL; Department of Paediatric Medicine, Antwerp University Hospital, Belgium., Hendriks JMH; Department of Thoracic and Vascular Surgery, Antwerp University Hospital, Belgium.
Jazyk:	angličtina
Zdroj:	Acta chirurgica Belgica [Acta Chir Belg] 2021 Jun; Vol. 121 (3), pp. 184-188. Date of Electronic Publication: 2019 Dec 03.
DOI:	10.1080/00015458.2019.1696516
Abstrakt:	Objective: There is still no consensus regarding the treatment of empyema in children. Intrapleural combination of tissue plasminogen activator and dornase alfa is a promising treatment for empyema in adults. The aim of this pilot study was to determine whether this combination is safe and successful in pediatric empyema. Methods: Previous well children diagnosed with empyema as classified by the British Thoracic Society. After chest tube insertion, intrapleurally dornase alfa 2.5 mg for 2 days and tissue plasminogen activator 0.15 mg/kg for 3 days was given after which the chest tube was clamped for 4 h. Primary outcome was safety. Results: Ten consecutive children were included (4 boys, aged 3.2 (1.3-15.0) years old). No serious adverse events were seen. One child developed urticaria but additional intervention or cessation of the trial was not needed. There was no bleeding or mortality and no additional procedures were performed. The median hospital stay after intervention was 7.5 days. Conclusions: The intrapleural treatment of dornase alfa and tissue plasminogen activator as treatment of empyema was safe in ten children with empyema. If confirmed in further studies, this combination of intrapleural therapy may improve the management of pediatric empyema.
Databáze:	MEDLINE
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