[Immunological markers of defeat of nervous tissue as an element of predictive model of damage of nervous system at syphilis.]

Autor:	Novikov YA; Department of a dermatovenereology and cosmetology «Omsk state medical university», 644001, Omsk, Russia., Indutny AV; Department of clinical laboratory diagnostics «Omsk state medical university», 644001, Omsk, Russia., Kravchenko EN; Clinical dermatovenerologic clinic, 644001, Omsk, Russia.
Jazyk:	ruština
Zdroj:	Klinicheskaia laboratornaia diagnostika [Klin Lab Diagn] 2019; Vol. 64 (11), pp. 659-662.
DOI:	10.18821/0869-2084-2019-64-11-659-662
Abstrakt:	To develop predictive model of damage of nervous system on the basis of definition of concentration of interleukins-23, 12p40 and also a glial fibrillar acid protein (GFAP) in liquor of patients with various forms of syphilis. Comprehensive laboratory examination of patients with neurosyphilis and syphilis without specific damage of nervous system who were observed in venereologic office of BOUZAS of OO «Clinical Dermatovenerologic Clinic» of Omsk is conducted. To all patients were carried out: a serological blood analysis, serological and clinical trial of liquor, and also immunological research of liquor (interleukins - 23, 12p40, and also GFAP). On the basis of the research IL-23, SILT-12p40, GFAP, the level of protein and a pleocytosis in liquor the predictive model of development of neurosyphilis in patients with syphilis without specific damage of nervous system is offered. The analysis of immunological changes in liquor of patients showed that the research of a number of cytokines and markers of damage of nervous tissue to liquor as the most specific and reliable, especially in the absence of clinical symptomatology from central nervous system can be an integral part of diagnostics of neurosyphilis also. Competing Interests: The authors declare no conflict of interest.
Databáze:	MEDLINE
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