| Autor: |
Hee C; School of Molecular Sciences, The University of Western Australia, 35 Stirling Hwy, Crawley, WA 6009, Australia. swaminatha.iyer@uwa.edu.au marck.norret@uwa.edu.au., Ho D, Karton A, Nealon G, Kretzmann JA, Norret M, Iyer KS |
| Jazyk: |
angličtina |
| Zdroj: |
Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2019 Nov 28; Vol. 55 (96), pp. 14506-14509. |
| DOI: |
10.1039/c9cc06603a |
| Abstrakt: |
Polymers are an attractive anchoring platform for the synthesis of radioimmunoconjugates. They enable independent control over the amount of radioisotope loading and antibody attachment, which is pivotal in developing tailorable formulations for personalised medicine. Herein, we report the synthesis of p(HEMA-ran-GMA) for the conjugation of lutetium ions and rituximab as a functional platform for radioimmunotherapy. We demonstrate the suitability of this platform using non-Hodgkin's lymphoma cells. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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