| Autor: |
Shi L; State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Biology , Hunan University , Changsha 410082 , P. R. China., Zeng Y; State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Biology , Hunan University , Changsha 410082 , P. R. China., Zhao Y; Center for Regenerative Medicine, State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology , Chinese Academy of Sciences , Beijing 100101 , P. R. China., Yang B; Center for Regenerative Medicine, State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology , Chinese Academy of Sciences , Beijing 100101 , P. R. China., Ossipov D; Department of Biosciences and Nutrition , Karolinska Institute , Häsovägen 7c , Huddinge 14157 , Sweden., Tai CW; Department of Materials and Environmental Chemistry , Stockholm University , Stockholm 10691 , Sweden., Dai J; Center for Regenerative Medicine, State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology , Chinese Academy of Sciences , Beijing 100101 , P. R. China., Xu C; School of Materials Science and Engineering , Xi'an University of Science and Technology , Xi'an 710054 , P. R. China. |
| Abstrakt: |
Magnetic hydrogel that can respond to a magnetic stimulus is a promising biomaterial for tissue regeneration and cancer treatment. In this study, a novel magnetic hydrogel is formed by simply mixing bisphosphonate (BP)-modified hyaluronic acid (i.e., HA-BP) polymeric solution and iron oxide (Fe 3 O 4 ) nanoparticle dispersion, in which the hydrogel networks are cross-linked by BP groups and iron atoms on the surface of particle. The iron-BP coordination chemistry affords a dynamic network, characterized by self-healing, shear-thinning, and smoothly injectable properties. Moreover, the HA-BP·Fe 3 O 4 magnetic hydrogel demonstrates heat-generation characterization under an alternating magnetic field. The animal experiments confirm the biocompatibilities of HA-BP·Fe 3 O 4 hydrogel, which presents the hydrogels potential for tissue regeneration and anticancer treatment applications. |
