Efficacy and Safety of Paliperidone Palmitate Treatment in Patients With Schizophrenia: A Real-World Multicenter, Retrospective, Mirror-Image Study.

Autor:	Devrimci-Ozguven H; From the Department of Psychiatry, Ankara University School of Medicine, Ankara., Atmaca M; Department of Psychiatry, Firat University School of Medicine, Elaziğ., Baran Z; Bakirköy Hospital of Mental Health and Neurological Diseases, Istanbul., Cengisiz C; Kozan Public Mental Health Centre, Adana., Çinar C; Manisa Hospital of Mental Health and Diseases, Manisa., Erol A; Department of Psychiatry, Sakarya University Training and Research Hospital Internal Medical Sciences, Sakarya., Genç Y; Yedikule Surp Pirgiç Armenian Hospital, Istanbul., Karadağ H; Psychiatry Clinic, Ankara Dişkapi Yildirim Beyazit Training and Research Hospital, Ankara., Karakülah K; Tokat Hospital of Mental Health and Diseases, Tokat., Karasu U; Balikesir State Hospital Public Mental Health Centre, Balikesir., Kaya MC; Department of Psychiatry, Dicle University School of Medicine, Diyarbakir., Kizil E; Boylam Psychiatry Hospital, Ankara., Özcan H; Department of Psychiatry, Atatürk University Research Hospital, Erzurum., Tiryaki A; Department of Psychiatry, Karadeniz Technical University School of Medicine, Trabzon.; Department of Psychiatry, Istanbul Aydin University School of Medicine., Üçok A; Department of Psychiatry, Istanbul University Istanbul School of Medicine., Varlik C; Bakirköy Hospital of Mental and Neurological Diseases, Public Mental Health Centre., Yazar SM; Bakirköy Hospital of Mental Health and Neurological Diseases., Yildiz M; Department of Psychiatry, Marmara University School of Medicine, Istanbul, Turkey.
Jazyk:	angličtina
Zdroj:	Journal of clinical psychopharmacology [J Clin Psychopharmacol] 2019 Nov/Dec; Vol. 39 (6), pp. 604-610.
DOI:	10.1097/JCP.0000000000001133
Abstrakt:	Purpose: The aim of the study was to assess efficacy and safety of paliperidone palmitate (PP) in schizophrenic patients using real-life data. Methods: This national, multicenter, retrospective, and mirror-image study was performed reviewing the medical records of patients in 18 centers. Adult schizophrenic patients receiving PP treatment (n = 205) were enrolled. Patients' data covering the last 12 months before the initial PP injection and the period until the end of study with at least 12 months after the initial PP injection were evaluated. Patients' characteristics, scale scores, and adverse events were recorded. Results: Nonadherence to prior medication was the most frequent reason for switching to PP treatment. Comparing with the period before PP treatment, the rate of patients visiting the hospital for relapse (79.5% vs 28.9%, P < 0.001) and the median number of hospitalizations (2 vs 0, P < 0.001) were lower during PP treatment. During PP treatment, the Positive and Negative Syndrome Scale score decreased by 20% or more (response to treatment) in 75.7% of the patients. The frequency of adverse events did not differ between the period before and during PP treatment. Improvement in functionality was higher in those with disease duration of 5 years or less. Conclusions: Paliperidone palmitate is effective and safe in treatment of schizophrenic patients and in switching to PP treatment in patients with schizophrenia, which reduced the percentage of patients admitted to the hospital for relapse and the median number hospitalization, and has positive effects on functionality.
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu