Interplay between host-microbe and microbe-microbe interactions in cystic fibrosis.

Autor: Armbruster CR; Microbiology and Molecular Genetics, University of Pittsburgh, United States. Electronic address: c4therine@pitt.edu., Coenye T; Laboratory of Pharmaceutical Microbiology, Ghent University, Belgium., Touqui L; Cystic Fibrosis: Physiopathology and Phenogenomics, CRSA Pasteur Institute and Hôpital Saint-Antoine, France., Bomberger JM; Microbiology and Molecular Genetics, University of Pittsburgh, United States.
Jazyk: angličtina
Zdroj: Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society [J Cyst Fibros] 2020 Mar; Vol. 19 Suppl 1, pp. S47-S53. Date of Electronic Publication: 2019 Nov 02.
DOI: 10.1016/j.jcf.2019.10.015
Abstrakt: The respiratory tract of individuals with cystic fibrosis is host to polymicrobial infections that persist for decades and lead to significant morbidity and mortality. Improving our understanding of CF respiratory infections requires coordinated efforts from researchers in the fields of microbial physiology, genomics, and ecology, as well as epithelial biology and immunology. Here, we have highlighted examples from recent CF microbial pathogenesis literature of how the host nutritional environment, immune response, and microbe-microbe interactions can feedback onto each other, leading to diverse effects on lung disease pathogenesis in CF.
Competing Interests: Declaration of Competing Interest The authors have no conflict of interest.
(Copyright © 2019 European Cystic Fibrosis Society. Published by Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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