Does Croton Argyrophyllus Extract Has an Effect on Muscle Damage and Lipid Peroxidation in Rats Submitted to High Intensity Strength Exercise?

Autor:	de Araújo SS; Post-Graduate Program in Physical Education, Federal University of Sergipe, São Cristóvão SE 49100-000, Brazil. silvan.ssa@gmail.com., Aidar FJ; Post-Graduate Program in Physical Education, Federal University of Sergipe, São Cristóvão SE 49100-000, Brazil. fjaidar@gmail.com.; Post-Graduate Program in Physiological Sciences, Federal University of Sergipe, São Cristóvão SE 49100-000, Brazil. fjaidar@gmail.com.; Group of Studies and Research of Performance, Sport, Health and Paralympic Sports-GEPEPS, Federal University of Sergipe, São Cristovão, Sergipe 49100-000, Brazil. fjaidar@gmail.com.; Department of Physical Education, Federal University of Sergipe, São Cristóvão, Sergipe 49100-000, Brazil. fjaidar@gmail.com.; Department of Physiology, Federal University of Sergipe, São Cristóvão, SE 49100-000, Brazil. fjaidar@gmail.com., Matos DG; Group of Studies and Research of Performance, Sport, Health and Paralympic Sports-GEPEPS, Federal University of Sergipe, São Cristovão, Sergipe 49100-000, Brazil. dihogogmc@hotmail.com.; Institute of Parasitology, McGill University, Montreal, QC H9X 3V9, Canada. dihogogmc@hotmail.com., Santos JLD; Post-Graduate Program in Biotechnology, Northeast Network in Biotechnology (RENORBIO), Federal University of Sergipe, São Cristóvão SE 49100-000, Brazil. jymmyslopes@yahoo.com.br., Souza LMV; Post-Graduate Program in Biotechnology, Northeast Network in Biotechnology (RENORBIO), Federal University of Sergipe, São Cristóvão SE 49100-000, Brazil. jymmyslopes@yahoo.com.br., Silva AND; Exercise's Inflammation and Immunology Laboratory, Sports Center, Federal University of Ouro Preto, Minas Gerais 35400-000, Brazil. jymmyslopes@yahoo.com.br., Dos Santos RM; Post-Graduate Program in Physiological Sciences, Federal University of Sergipe, São Cristóvão SE 49100-000, Brazil. rms.edf@hotmail.com.; Department of Circulation and Medical Imaging, St. Olav's Hospital, Norwegian University of Science and Technology (NTNU), Trondheim NO-0508, Norway. rms.edf@hotmail.com., Marçal AC; Post-Graduate Program in Physical Education, Federal University of Sergipe, São Cristóvão SE 49100-000, Brazil. acmarcal@yahoo.com.br., Mourão DM; Department of Medical Clinic, State University of Montes Claros, MG 39401-089, Brazil. daniella_mourao@hotmail.com., Júnior AL; Department of Physical Education, State University of Montes Claros, Montes Claros, MG 39401-089, Brazil. lessauni@gmail.com., Durães GM; Department of Physical Education, State University of Montes Claros, Montes Claros, MG 39401-089, Brazil. gmdmoc@yahoo.com.br., Carneiro ALG; Department of Physical Education, State University of Montes Claros, Montes Claros, MG 39401-089, Brazil. algcarneiro@gmail.com., Silva RGD; Department of Physical Education, University Funorte of Montes Claros, Montes Claros, MG 39401-089, Brazil. rodrigo.edfisio@yahoo.com.br., Teixeira MM; Department of Pathology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte 31270-901, Brazil. mmtex.ufmg@gmail.com., Dos Santos Estevam C; Department of Physiology, Federal University of Sergipe, São Cristóvão, SE 49100-000, Brazil. cse.ufs@gmail.com.; Post-Graduate Program in Biotechnology, Northeast Network in Biotechnology (RENORBIO), Federal University of Sergipe, São Cristóvão SE 49100-000, Brazil. cse.ufs@gmail.com.
Jazyk:	angličtina
Zdroj:	International journal of environmental research and public health [Int J Environ Res Public Health] 2019 Oct 31; Vol. 16 (21). Date of Electronic Publication: 2019 Oct 31.
DOI:	10.3390/ijerph16214237
Abstrakt:	Many species of the genus Croton have been used for anti-inflammatory, antiproliferative, antidiabetic, and antitumor purposes. The objective was to evaluate the effect of a hydroethanolic extract (HEE) from the inner bark of Croton argyrophyllus (Euphorbiaceae) on muscle damage and oxidative stress in rats after high intensity exercise. The animals were divided into four groups: (i) the sedentary group (SV; n = 7), (ii) the exercise vehicle group (EV, n = 7), (iii) the sedentary group HEE (SHG; n = 7) composed of sedentary animals and treated with the hydroethanolic extract of C. argyrophyllus (200 mg/kg, v.o.), and (iv) the HEE exercise group (HEE; n = 7) composed of animals submitted to resistance exercise (RE) and treated with the hydroethanolic extract of C. argyrophyllus (200 mg/kg, v.o.). In the 2,2-Diphenyl-1-picrylhydrazyl (DPPH) test, the HEE showed lower values of inhibition potential (IP%) at 39.79% compared to gallic acid, 87.61%, and lipoperoxidation inhibition at 27.4% (100 µg/mL) or 28.6% (200 µg/mL) ( p < 0.001). There was inhibition in free radicals in vivo. The HEE of C. argyrophyllus partially reduced the biomarkers of oxidative stress in muscle tissue and muscular damage (creatine kinase (CK) and Lactate Dehydrogenase (LDH)) ( p < 0.05) in rats, and in this sense it can be an aid to the recovery process after exhaustive efforts. Competing Interests: The authors declare no conflict of interest.
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu